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ubiquitin specific peptidase 48

Summary

Gene Symbol

USP48

Organism

Homo sapiens (human)

External Links

NCBI Gene

84196

PubChem

84196

Alliance of Genome Resources

HGNC:18533

Annotation

Keyword

Acetylation
Alternative splicing
Cell projection
Cytoplasm
Non-syndromic deafness
Nucleus
Phosphoprotein
Reference proteome
Repeat
Thiol protease
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q86UV5	Deubiquitinating enzyme 48 Ubiquitin thioesterase 48 Ubiquitin-specific peptidase 48 Ubiquitin-specific protease 48 Ubiquitin-specific-processing protease 48

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
proteolysis	IEA
protein deubiquitination	IEA
regulation of protein stability	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

biological regulation [inference]

regulation of biological quality [inference]

regulation of protein stability

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GO Term	Evidence Code	PMID
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA
mitochondrion	IDA
cytosol	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cysteine-type endopeptidase activity	IEA
cysteine-type deubiquitinase activity	IBA
protein binding	IPI	32814053
deubiquitinase activity	IDA	34059922

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity

cysteine-type deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity [inference]

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity

cysteine-type deubiquitinase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ubiquitin carboxyl-terminal hydrolase

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying 1 entry
Gene Ontology
hydrolase activity

Displaying **all 4** entries
InterPro
Papain-like cysteine peptidase superfamily
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Ubiquitin specific protease domain
Ubiquitin specific protease, conserved site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070605	autosomal dominant nonsyndromic deafness 85	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	84196	Xenbase:XB-GENE-5938602
Mus musculus	170707		MOUSE41294
Rattus norvegicus	362636		RATNO33413
Pan troglodytes	456602		PANTR20184
Canis lupus familiaris	478198		CANLF07065
Macaca mulatta	707110		MACMU22948
Monodelphis domestica	100023231		MONDO25387
Equus caballus	100058232		HORSE27627
Ornithorhynchus anatinus	100087092		ORNAN21698
Bos taurus	100141158		BOVIN25244

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OrthoDB (Group)

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Acknowledgements