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latent transforming growth factor beta binding protein 4

Summary

Gene Symbol

LTBP4

Organism

Homo sapiens (human)

External Links

NCBI Gene

8425

PubChem

8425

Alliance of Genome Resources

HGNC:6717

Annotation

Keyword

Alternative splicing
Disease variant
Disulfide bond
EGF-like domain
Extracellular matrix
Glycoprotein
Growth factor binding
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A0C4DH07
Q8N2S1
B3KXY6

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
protein folding	TAS	9660815
hormone secretion	IEA
transforming growth factor beta receptor signaling pathway	IEA
regulation of transforming growth factor beta receptor signaling pathway	TAS	9660815
regulation of cell growth	TAS	9660815

GO Hierarchy

biological process

cellular process [inference]

protein folding

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly [inference]

elastic fiber assembly

supramolecular fiber organization [inference]

elastic fiber assembly

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion

localization [inference]

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion

secretion [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of growth [inference]

regulation of cell growth

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular component organization [inference]

regulation of cell growth

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular matrix	IDA	9660815
microfibril	ISS
collagen-containing extracellular matrix	HDA IDA	16157329 20551380 25037231 27559042 28675934
extracellular region	HDA TAS	27068509
extracellular space	HDA	20551380

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

microfibril

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GO Term	Evidence Code	PMID
protein binding	IPI	12429738 19349279 21078624 27339457
integrin binding	NAS	9660815
transforming growth factor beta receptor activity	NAS	9660815
extracellular matrix structural constituent	RCA	20551380 25037231 27559042 28675934
glycosaminoglycan binding	NAS	9660815

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

growth factor binding [inference]

transforming growth factor beta binding

cytokine binding [inference]

transforming growth factor beta binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

integrin binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein kinase activity [inference]

transmembrane receptor protein serine/threonine kinase activity [inference]

transforming growth factor beta receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

vacuolar sorting receptor

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 3** entries
InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0070139	autosomal recessive cutis laxa type IC	Alliance of Genome Resources
DOID:3144	cutis laxa	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 48 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	108075		MGI:1321395	MOUSE52075
Rattus norvegicus	292734		RGD:1307033	RATNO15873
Canis lupus familiaris	444849			CANLF01053
Pan troglodytes	456044	9598_0:004bf5		PANTR18330
Macaca mulatta	100430897			MACMU18208
Pongo abelii	100447163	9601_0:004aa3		PONAB15382
Xenopus tropicalis	100488208		Xenbase:XB-GENE-992148
Nomascus leucogenys	100586520			NOMLE13097
Cavia porcellus	100724798			CAVPO23903
Bos taurus	100848191			BOVIN11116