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sterol O-acyltransferase 2

Summary

Gene Symbol

SOAT2

Aliases

ACAT2
acyl-Coenzyme A: cholesterol acyltransferase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

8435

HGNC

11178

KEGG Gene ID

hsa:8435

PubChem

8435

Alliance of Genome Resources

HGNC:11178

Annotation

Keyword

3D-structure
Acyltransferase
Alternative splicing
Cholesterol metabolism
Endoplasmic reticulum
Oxidation
Reference proteome
Thioester bond
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O75908	Acyl-coenzyme A:cholesterol acyltransferase 2 Cholesterol acyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
intestinal cholesterol absorption	IC	14615411
very-low-density lipoprotein particle assembly	IMP	15308631
macrophage derived foam cell differentiation		14615411
cholesterol storage	IEA
low-density lipoprotein particle clearance

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

foam cell differentiation [inference]

macrophage derived foam cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

protein-lipid complex organization [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

plasma lipoprotein particle clearance [inference]

low-density lipoprotein particle clearance

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

foam cell differentiation [inference]

macrophage derived foam cell differentiation

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

maintenance of location [inference]

lipid storage [inference]

cholesterol storage

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	15451793
endoplasmic reticulum membrane	IBA IDA TAS	12808042
brush border	IDA	14615411

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

cluster of actin-based cell projections [inference]

brush border

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
fatty-acyl-CoA binding	IBA IDA	16647063
cholesterol O-acyltransferase activity	IBA IDA TAS	16647063
cholesterol binding	IBA IDA	16647063
acyltransferase activity		9756920
protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

sterol O-acyltransferase activity

cholesterol O-acyltransferase activity

binding [inference]

protein binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

fatty acid derivative binding [inference]

fatty-acyl-CoA binding

amide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ion binding [inference]

anion binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

sulfur compound binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:59816

a sterol + a long-chain fatty acyl-CoA

a sterol ester + CoA

Enzyme

2.3.1.26

PMID

RHEA:17729

cholesterol + an acyl-CoA

a cholesterol ester + CoA

Enzyme

2.3.1.26

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 17 in total

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DO ID	Disease Name	Source
DOID:13739	nutmeg liver	DisGeNET
DOID:14497	Wolman disease	DisGeNET
DOID:0080217	lysosomal acid lipase deficiency	DisGeNET
DOID:10608	celiac disease	DisGeNET
DOID:1168	familial hyperlipidemia	DisGeNET
DOID:1184	nephrotic syndrome	Alliance of Genome Resources
DOID:162	cancer	DisGeNET
DOID:1936	atherosclerosis	DisGeNET DisGeNET DisGeNET
DOID:2348	arteriosclerotic cardiovascular disease	DisGeNET DisGeNET DisGeNET
DOID:2349	arteriosclerosis	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001184
Gene Name: sterol O-acyltransferase 2

Ortholog

Displaying entries **1 - 10** of 56 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	181681	WB:WBGene00007174
Drosophila melanogaster	41033	FB:FBgn0037612
Latimeria chalumnae	102367356		LATCH20104
Danio rerio	564868	ZFIN:ZDB-GENE-061013-742
Xenopus laevis	779411	Xenbase:XB-GENE-961306
Xenopus laevis	108708653	Xenbase:XB-GENE-17333690
Xenopus tropicalis	100216296	Xenbase:XB-GENE-961303
Sarcophilus harrisii	100933677		SARHA08635
Callithrix jacchus	100412165		CALJA45257
Cercocebus atys	105580285		CERAT25001

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Tools

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Summary

External Links

Annotation

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements