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sterol O-acyltransferase 2

Summary

Gene Symbol

SOAT2

Aliases

ACAT2
acyl-Coenzyme A: cholesterol acyltransferase 2

Organism

Homo sapiens (human)

External Links

NCBI Gene

8435

HGNC

11178

KEGG Gene ID

hsa:8435

PubChem

8435

Alliance of Genome Resources

HGNC:11178

Annotation

Keyword

3D-structure
Acyltransferase
Alternative splicing
Cholesterol metabolism
Endoplasmic reticulum
Oxidation
Reference proteome
Thioester bond
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O75908	Acyl-coenzyme A:cholesterol acyltransferase 2 Cholesterol acyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cholesterol metabolic process	IDA	11294643 16647063
cholesterol metabolic process	IBA
macrophage derived foam cell differentiation	TAS	14615411
cholesterol storage	IEA
intestinal cholesterol absorption	IC	14615411

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

foam cell differentiation [inference]

macrophage derived foam cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

protein-lipid complex organization [inference]

protein-lipid complex assembly [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

plasma lipoprotein particle clearance [inference]

low-density lipoprotein particle clearance

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle assembly [inference]

very-low-density lipoprotein particle assembly

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

foam cell differentiation [inference]

macrophage derived foam cell differentiation

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

intestinal absorption [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

intestinal lipid absorption [inference]

intestinal cholesterol absorption

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

maintenance of location [inference]

lipid storage [inference]

cholesterol storage

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	15451793
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA	12808042
endoplasmic reticulum membrane	IBA
brush border	IDA	14615411

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

cluster of actin-based cell projections [inference]

brush border

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
fatty-acyl-CoA binding	IDA	16647063
fatty-acyl-CoA binding	IBA
sterol O-acyltransferase activity	IDA	11294643
protein binding	IPI	32296183
cholesterol binding	IDA	16647063

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

sterol O-acyltransferase activity

cholesterol O-acyltransferase activity

binding [inference]

protein binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

fatty acid derivative binding [inference]

fatty-acyl-CoA binding

amide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

small molecule binding [inference]

alcohol binding [inference]

cholesterol binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ion binding [inference]

anion binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

organic cyclic compound binding [inference]

steroid binding [inference]

sterol binding [inference]

cholesterol binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

sulfur compound binding [inference]

acyl-CoA binding [inference]

fatty-acyl-CoA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

acyltransferase

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
O-acyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
Membrane bound O-acyl transferase, MBOAT
Sterol O-acyltransferase, ACAT/DAG/ARE types

Rhea

RHEA:17729

cholesterol + an acyl-CoA

a cholesterol ester + CoA

Enzyme

2.3.1.26

PMID

RHEA:59816

a sterol + a long-chain fatty acyl-CoA

a sterol ester + CoA

Enzyme

2.3.1.26

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001184
Gene Name: sterol O-acyltransferase 2

Ortholog

Displaying entries **1 - 10** of 52 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	6646	FB:FBgn0037612
Xenopus tropicalis	8435	Xenbase:XB-GENE-961303
Mus musculus	223920		MOUSE16798
Rattus norvegicus	266770		RATNO39021
Canis lupus familiaris	486511		CANLF10745
Bos taurus	513554		BOVIN29086
Macaca mulatta	701171		MACMU05274
Pan troglodytes	737291		PANTR05768
Equus caballus	100146367		HORSE37216
Oryctolagus cuniculus	100349393		RABIT10384

GlyTouCan

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UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements