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MIRAGE
hyperpolarization-activated cyclic nucleotide-gated potassium channel 1
Summary
- Gene Symbol
-
- Hcn1
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Cell membrane
- Glycoprotein
- Ligand-gated ion channel
- Potassium channel
- Reference proteome
- Sodium channel
- Transmembrane helix
- Voltage-gated channel
- cAMP-binding
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9JKB0 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| regulation of membrane depolarization | ||
| regulation of membrane depolarization | ||
| regulation of membrane depolarization | ||
| neuronal action potential | ||
| cellular response to interferon-beta |
GO Hierarchy
biological process
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| plasma membrane | ||
| cell surface | ||
| basolateral plasma membrane | ||
| axon |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| intracellular cAMP-activated cation channel activity | ||
| intracellular cAMP-activated cation channel activity | ||
| voltage-gated sodium channel activity | ||
| voltage-gated potassium channel activity | ||
| voltage-gated potassium channel activity |
GO Hierarchy
molecular function
transporter activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel
- Functional Category
-
- E: Amino acid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| monoatomic ion channel activity |
| monoatomic ion transport |
| regulation of membrane depolarization |
| sodium ion transmembrane transport |
| voltage-gated potassium channel activity |
| InterPro |
|---|
| Cyclic nucleotide-binding domain superfamily |
| Cyclic nucleotide-binding domain |
| Cyclic nucleotide-binding, conserved site |
| RmlC-like jelly roll fold |
Alliance of Genome Resources
- Expression
| Location | References |
|---|---|
Disease
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 330953 | FB:FBgn0263397 | ||
| 348980 | Xenbase:XB-GENE-950265 | HUMAN79096 | |
| 471552 | PANTR35604 | ||
| 538255 | BOVIN15960 | ||
| 612434 | CANLF14964 | ||
| 704286 | MACMU37890 | ||
| 100008732 | RABIT01954 | ||
| 100064345 | HORSE20169 | ||
| 100334297 | DANRE21601 | ||
| 100386968 | CALJA24829 |
