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Guidelines

MIRAGE

glyceronephosphate O-acyltransferase

Summary

Gene Symbol

GNPAT

Aliases

DAP-AT
DAPAT
DHAPAT
dihydroxyacetone phosphate acyltransferase
glycerone-phosphate O-acyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

8443

HGNC

4416

KEGG Gene ID

hsa:8443

PubChem

8443

Alliance of Genome Resources

HGNC:4416

JoGo

GNPAT

TogoVar

GNPAT

Annotation

Keyword

Acetylation
Acyltransferase
Alternative splicing
Cataract
Direct protein sequencing
Disease variant
Dwarfism
Membrane
Peroxisome
Phosphoprotein
Proteomics identification
Reference proteome
Rhizomelic chondrodysplasia punctata

Proteins

Displaying 1 entry
UniProt	Protein Name
O15228	Acyl-CoA:dihydroxyacetonephosphateacyltransferase Glycerone-phosphate O-acyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
fatty acid metabolic process
phosphatidic acid biosynthetic process	TAS
synapse assembly	IEA
response to nutrient	IEA
ether lipid biosynthetic process	TAS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

ether metabolic process [inference]

glycerol ether metabolic process [inference]

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

ether metabolic process [inference]

glycerol ether metabolic process [inference]

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

ether biosynthetic process [inference]

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerol ether biosynthetic process [inference]

ether lipid biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

phospholipid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

ether lipid metabolic process [inference]

ether lipid biosynthetic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride biosynthetic process

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid metabolic process [inference]

phosphatidic acid metabolic process [inference]

phosphatidic acid biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

triglyceride biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidic acid biosynthetic process

cellular lipid biosynthetic process [inference]

ether lipid biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

paranodal junction assembly

cell junction assembly [inference]

cell-cell junction assembly [inference]

paranodal junction assembly

synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

paranodal junction assembly

synapse assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

paranodal junction assembly

synapse organization [inference]

synapse assembly

membrane organization

developmental process [inference]

anatomical structure morphogenesis [inference]

cerebellum morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

paranodal junction assembly

response to stimulus [inference]

response to stress [inference]

response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to chemical [inference]

response to organic substance [inference]

response to lipid [inference]

response to fatty acid

response to oxygen-containing compound [inference]

response to fatty acid

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
peroxisome	NAS	9459311
peroxisome	IDA	15687349
peroxisomal membrane	TAS
peroxisomal membrane	IBA
peroxisomal membrane	HDA	21525035

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle membrane [inference]

mitochondrial membrane

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

cell junction

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

intracellular organelle [inference]

intracellular membrane-bounded organelle

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glycerol-3-phosphate O-acyltransferase activity
glycerone-phosphate O-acyltransferase activity	TAS
glycerone-phosphate O-acyltransferase activity	IDA	10395968 11152660 15687349 8186247 9536089
glycerone-phosphate O-acyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity [inference]

glycerol-3-phosphate O-acyltransferase activity

O-acetyltransferase activity [inference]

glycerone-phosphate O-acyltransferase activity

acetyltransferase activity [inference]

O-acetyltransferase activity [inference]

glycerone-phosphate O-acyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

acyltransferase

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 10** entries
Gene Ontology
O-acyltransferase activity
cellular lipid metabolic process
ether lipid biosynthetic process
fatty acid metabolic process
glycerol-3-phosphate O-acyltransferase activity
glycerol-3-phosphate metabolic process
glycerone-phosphate O-acyltransferase activity
phospholipid biosynthetic process
transferase activity
triglyceride biosynthetic process

Displaying **all 4** entries
InterPro
GPAT/DHAPAT, C-terminal domain
GPAT/DHAPAT, acyltransferase domain
Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
Phospholipid/glycerol acyltransferase

Rhea

dihydroxyacetone phosphate + an acyl-CoA

CoA + a 1-acylglycerone 3-phosphate

Enzyme

2.3.1.42

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110852	rhizomelic chondrodysplasia punctata type 2	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 36 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000023	Inguinal hernia
HP:0000176	Submucous cleft hard palate
HP:0000218	High palate
HP:0000239	Large fontanelles
HP:0000252	Microcephaly
HP:0000347	Micrognathia
HP:0000348	High forehead
HP:0000431	Wide nasal bridge
HP:0000463	Anteverted nares

Displaying 1 entry
Disease ID	Disease Name
OMIM:222765	rhizomelic chondrodysplasia punctata type 2

PubChem Disease

GHR Health Conditions

Rhizomelic chondrodysplasia punctata

MedGen Diseases

Rhizomelic chondrodysplasia punctata type 2

OMIM Phenotypes

RHIZOMELIC CHONDRODYSPLASIA PUNCTATA, TYPE 2; RCDP2

KEGG Diseases

Rhizomelic chondrodysplasia punctata

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001078
Gene Name: glyceronephosphate O-acyltransferase

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026