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quiescin sulfhydryl oxidase 1

Summary

Gene Symbol

Qsox1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

84491

PubChem

84491

Alliance of Genome Resources

RGD:68957

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disulfide bond
FAD
Glycoprotein
Golgi apparatus
Oxidoreductase
Reference proteome
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6IUU3	FAD-dependent sulfhydryl oxidase-2 Quiescin Q6
A6ICZ3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein folding	IBA
negative regulation of macroautophagy	ISO
extracellular matrix assembly	ISO

GO Hierarchy

biological process

cellular process [inference]

protein folding

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

extracellular matrix assembly

extracellular structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

extracellular matrix assembly

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
extracellular exosome	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intercellular bridge

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein disulfide isomerase activity	IBA ISO ISS
FAD binding	IDA ISO	24888638
flavin-dependent sulfhydryl oxidase activity	IBA IDA ISO ISS	11278790

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

protein-disulfide reductase activity [inference]

flavin-dependent sulfhydryl oxidase activity

thiol oxidase activity [inference]

flavin-dependent sulfhydryl oxidase activity

oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [inference]

thiol oxidase activity [inference]

flavin-dependent sulfhydryl oxidase activity

isomerase activity [inference]

intramolecular oxidoreductase activity [inference]

intramolecular oxidoreductase activity, transposing S-S bonds [inference]

protein disulfide isomerase activity

catalytic activity, acting on a protein [inference]

protein disulfide isomerase activity

protein-disulfide reductase activity [inference]

flavin-dependent sulfhydryl oxidase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

ion binding [inference]

anion binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

flavin adenine dinucleotide binding [inference]

FAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Sulfhydryl oxidase

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 3** entries
Gene Ontology
flavin-dependent sulfhydryl oxidase activity
oxidoreductase activity
thiol oxidase activity

Displaying **all 4** entries
InterPro
ERV/ALR sulfhydryl oxidase domain
Sulfhydryl oxidase, Trx-like domain
Sulfhydryl oxidase, flavin adenine dinucleotide (FAD) binding domain
Thioredoxin domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14679	VACTERL association	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of **105** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Ailuropoda melanoleuca	100465501			AILME11189
Anolis carolinensis	100563795			ANOCA05761
Nomascus leucogenys	100596713			NOMLE05821
Loxodonta africana	100665320			LOXAF13700
Oreochromis niloticus	100706190			ORENI44256
Cricetulus griseus	100754501	10029_0:003564
Otolemur garnettii	100967170			OTOGA15396
Pan paniscus	100974942			PANPA03250
Papio anubis	101024738			PAPAN20688
Takifugu rubripes	101077738			TAKRU26646

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Last updated: December 9, 2024