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Standards Ontologies Notations
ST6 beta-galactoside alpha-2,6-sialyltransferase 2

Summary
Gene Symbol
  • ST6GAL2
Aliases
  • KIAA1877
  • St6GalII
Organism
Homo sapiens (human)
NCBI Gene
84620
GGDB ID
HGNC
10861
mRNA
map
  • 2q11.2-q12.1
Protein
OMIM
KEGG Gene ID
hsa:84620
PubChem
84620
Alliance of Genome Resources
Annotation
Keyword
  • Alternative splicing
  • Disulfide bond
  • Glycoprotein
  • Glycosyltransferase
  • Golgi apparatus
  • Reference proteome
  • Signal-anchor
  • Transmembrane helix
Proteins
Displaying 1 entry
UniProt Protein Name
Q96JF0
  • CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
  • ST6Gal II
  • Sialyltransferase 2
Annotation information from UniProt.
Gene Ontology (GO)
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
Sialyltransferase
Functional Category
  • H: Coenzyme transport and metabolism
  • M: Cell wall/membrane/envelope biogenesis
  • T: Signal transduction mechanisms
Displaying all 2 entries
Gene Ontology
sialyltransferase activity
transferase activity
Displaying all 2 entries
InterPro
GT29-like superfamiliy
Glycosyl transferase family 29
GlycoGene Database (GGDB)
GGDB ID
gg055
Gene Symbol
  • ST6GAL2
Reactions
Displaying all 2 entries
Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
CMP-Neu5Ac
G00057MO
Free
G54118CT
Free
CMP-Neu5Ac
G58896AZ
Free
G83513YI
Free
Displaying all 2 entries
Donor Acceptor Reducing terminal(Acceptor) Product Reducing terminal(Product) Reference
CMP-Neu5Ac
G00057MO
Free
G54118CT
Free
CMP-Neu5Ac
G58896AZ
Free
G83513YI
Free
Displaying entries 1 - 5 of 8 in total
Donor Acceptor Reducing terminal(Acceptor) Reference
CMP-Neu5Ac
G65889KE
para-nitrophenol
CMP-Neu5Ac
G00056MO
-O-octyl
CMP-Neu5Ac
G49108TO
para-nitrophenol
CMP-Neu5Ac
G57321FI
para-nitrophenol
CMP-Neu5Ac
G00056MO
free
Orthologous Gene
Displaying all 3 entries
Species Protein mRNA
Drosophila melanogaster NP_726474 NM_166684
Rattus norvegicus XP_236826 XM_236826
Mus musculus NP_766417 NM_172829
KEGG BRITE Database
Orthology
K00779
Name
beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 2) [EC:2.4.3.1]
References
Reactions
Displaying 1 entry
KEGG Reaction Enzyme Acceptor Product
R06188
Rhea

RHEA:21552

a β-D-Gal-(1→4)-β-D-Glc-(1↔1)-Cer(d18:1(4E)) + CMP-N-acetyl-β-neuraminate
H+ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-β-D-glucosyl-(1↔1)-ceramide + CMP
Enzyme
PMID

RHEA:11836

N-acetyl-β-lactosamine + CMP-N-acetyl-β-neuraminate
H+ + N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosamine + CMP
Enzyme
PMID

RHEA:52104

a β-D-galactoside + CMP-N-acetyl-β-neuraminate
an N-acetyl-α-neuraminyl-(2→6)-β-D-galactosyl derivative + H+ + CMP
Enzyme
PMID
Ortholog
Displaying entries 1 - 10 of 72 in total
Species Gene ID OrthoDB Alliance of Genome Resources Orthologous MAtrix
37950 FB:FBgn0035050
240119 MGI:2445190 MOUSE20017
301155 RGD:1559663 RATNO43159
403116 ZFIN:ZDB-GENE-060322-4
407846 Xenbase:XB-GENE-990439
450198 9598_0:000949 PANTR28394
481315 CANLF01725
493992 BOVIN02467
713552 MACMU07601
797439 ZFIN:ZDB-GENE-120426-2
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024