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Standards Ontologies Notations
Guidelines
MIRAGE
calcium sensing receptor

Summary
Gene Symbol
  • CASR
Organism
Homo sapiens (human)
NCBI Gene
846
PubChem
846
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Alternative splicing
  • Calcium
  • Cell membrane
  • Disease variant
  • Disulfide bond
  • Epilepsy
  • G-protein coupled receptor
  • Glycoprotein
  • Metal-binding
  • Phosphoprotein
  • Reference proteome
  • Signal
  • Transmembrane helix
  • Ubl conjugation
Proteins
Displaying 1 entry
UniProt Protein Name
P41180
  • Parathyroid cell calcium-sensing receptor 1
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 16 - 20 of 35 in total
GO Term Evidence Code PMID
positive regulation of insulin secretion
bile acid secretion
cellular response to hepatocyte growth factor stimulus
vasodilation
positive regulation of vasoconstriction
GO Hierarchy
Displaying entries 1 - 5 of 12 in total
GO Term Evidence Code PMID
phosphatidylinositol phospholipase C activity
G protein-coupled receptor activity
G protein-coupled receptor activity
integrin binding
calcium ion binding
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
metabotropic glutamate receptor
Functional Category
  • E: Amino acid transport and metabolism
  • M: Cell wall/membrane/envelope biogenesis
  • T: Signal transduction mechanisms
Displaying all 7 entries
InterPro
GPCR family 3, C-terminal
GPCR, family 3, extracellular calcium-sensing receptor-related
GPCR, family 3, nine cysteines domain superfamily
GPCR, family 3, nine cysteines domain
GPCR, family 3
Periplasmic binding protein-like I
Receptor, ligand binding region
Disease
Disease Ontology
Displaying all 10 entries
DO ID Disease Name Source
DOID:0060700 familial hypocalciuric hypercalcemia 1
DOID:0080652 calcium oxalate nephrolithiasis
DOID:0090107 autosomal dominant hypocalcemia 1
DOID:0090109 autosomal dominant hypocalcemia
DOID:0111322 obsolete idiopathic generalized epilepsy 8
DOID:1059 intellectual disability
DOID:12466 secondary hyperparathyroidism
DOID:12678 hypercalcemia
DOID:13543 hyperparathyroidism
DOID:585 nephrolithiasis
Ortholog
Displaying entries 1 - 10 of 102 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
846 Xenbase:XB-GENE-6065247
12374 Xenbase:XB-GENE-6065247 MOUSE19497
24247 Xenbase:XB-GENE-6065247 RATNO04089
281038 BOVIN14608
460628 PANTR31977
488007 CANLF13351
560607 DANRE37362
714441 MACMU27925
100018274 MONDO22815
100034084 HORSE14350
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025