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cytochrome c oxidase subunit 4I2

Summary

Gene Symbol

COX4I2

Organism

Homo sapiens (human)

External Links

NCBI Gene

84701

PubChem

84701

Alliance of Genome Resources

HGNC:16232

Annotation

Keyword

Disease variant
Mitochondrion inner membrane
Reference proteome
Transit peptide
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q96KJ9	Cytochrome c oxidase subunit IV isoform 2
H6SG14

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
generation of precursor metabolites and energy	NAS	11311561
mitochondrial electron transport, cytochrome c to oxygen	IBA IDA	11311561
cellular respiration	NAS	11911854
proton transmembrane transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy

energy derivation by oxidation of organic compounds [inference]

cellular respiration

aerobic respiration [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

electron transport chain [inference]

respiratory electron transport chain [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy

energy derivation by oxidation of organic compounds [inference]

cellular respiration

aerobic respiration [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

electron transport chain [inference]

respiratory electron transport chain [inference]

aerobic electron transport chain [inference]

mitochondrial electron transport, cytochrome c to oxygen

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrial respiratory chain complex IV
mitochondrial inner membrane
mitochondrion	HTP	34800366
respiratory chain complex IV	IBA IC	11311561
mitochondrial intermembrane space

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

inner mitochondrial membrane protein complex [inference]

mitochondrial respiratory chain complex IV

respiratory chain complex [inference]

respiratory chain complex IV

mitochondrial respiratory chain complex IV

mitochondrial protein-containing complex [inference]

inner mitochondrial membrane protein complex [inference]

mitochondrial respiratory chain complex IV

catalytic complex [inference]

cytochrome complex [inference]

respiratory chain complex IV

mitochondrial respiratory chain complex IV

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

organelle envelope lumen [inference]

mitochondrial intermembrane space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying 1 entry
GO Term	Evidence Code	PMID
cytochrome-c oxidase activity	IDA	11311561

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity [inference]

cytochrome-c oxidase activity

oxidoreductase activity, acting on a heme group of donors [inference]

cytochrome-c oxidase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

oxidoreduction-driven active transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cytochrome C oxidase

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
mitochondrial electron transport, cytochrome c to oxygen

Displaying **all 2** entries
InterPro
Cytochrome c oxidase subunit IV family
Cytochrome c oxidase subunit IV superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3762	cytochrome-c oxidase deficiency disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	35279		FB:FBgn0032833
Mus musculus	84682		MGI:2135755	MOUSE31542
Rattus norvegicus	84683		RGD:69422	RATNO28992
Caenorhabditis elegans	173237		WB:WBGene00012354
Xenopus laevis	379593		Xenbase:XB-GENE-17345285
Danio rerio	393776		ZFIN:ZDB-GENE-040426-1775
Xenopus laevis	444815		Xenbase:XB-GENE-6254169
Pan troglodytes	469913	9598_0:00515f		PANTR24584
Xenopus tropicalis	549699		Xenbase:XB-GENE-5872512
Macaca mulatta	713095			MACMU01275

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OrthoDB (Group)

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Acknowledgements