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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
ORAI calcium release-activated calcium modulator 1
Summary
- Gene Symbol
-
- ORAI1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Adaptive immunity
- Alternative initiation
- Calcium channel
- Calmodulin-binding
- Cell membrane
- Disease variant
- Glycoprotein
- Phosphoprotein
- Reference proteome
- Transmembrane helix
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| Q96D31 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| calcineurin-NFAT signaling cascade | ||
| ligand-gated ion channel signaling pathway | ||
| calcium ion import | ||
| phospholipase C-activating G protein-coupled receptor signaling pathway | ||
| mammary gland epithelium development |
GO Hierarchy
biological process
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| calmodulin binding | ||
| store-operated calcium channel activity | ||
| calcium channel activity | ||
| identical protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Calcium release-activated calcium channel protein 1
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| store-operated calcium channel activity |
| store-operated calcium entry |
| InterPro |
|---|
| Calcium release-activated calcium channel protein |
| Orai superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080686 | tubular aggregate myopathy 2 | |
| DOID:0111976 | immunodeficiency 9 | |
| DOID:11984 | hypertrophic cardiomyopathy | |
| DOID:12930 | dilated cardiomyopathy |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 105590966 | CERAT12729 | |||
| 105825594 | PROCO07066 | |||
| 105990658 | DIPOR17490 | |||
| 106842218 | EQUAS13951 | |||
| 108529632 | RHIBE21910 | |||
| 108707681 | Xenbase:XB-GENE-17345572 | |||
| 109312628 | CROPO19283 | |||
| 110196793 | PHACI10969 | |||
| 113486098 | ATHCN16332 | |||
| 113907545 | BOBOX33074 |
