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ORAI calcium release-activated calcium modulator 1

Summary

Gene Symbol

ORAI1

Organism

Homo sapiens (human)

External Links

NCBI Gene

84876

PubChem

84876

Alliance of Genome Resources

HGNC:25896

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative initiation
Calcium channel
Calmodulin-binding
Cell membrane
Disease variant
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96D31	Protein orai-1 Transmembrane protein 142A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
regulation of calcium ion transport	IMP	16921383
positive regulation of calcium ion transport	IDA	16645049 16733527 16766533 16807233
store-operated calcium entry	IBA IDA	16921383 19182790 26221052 28219928 32415068

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

calcineurin-mediated signaling [inference]

calcineurin-NFAT signaling cascade

ligand-gated ion channel signaling pathway

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

mammary gland epithelium development

response to stimulus [inference]

immune response [inference]

adaptive immune response

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport

organic substance transport [inference]

calcium ion transport [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport

positive regulation of calcium ion transport

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

regulation of secretion [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of transport [inference]

positive regulation of monoatomic ion transport [inference]

positive regulation of calcium ion transport

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling [inference]

calcineurin-mediated signaling [inference]

calcineurin-NFAT signaling cascade

ligand-gated ion channel signaling pathway

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

positive regulation of protein secretion [inference]

positive regulation of insulin secretion

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity

regulation of catalytic activity [inference]

regulation of cyclase activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity

positive regulation of catalytic activity [inference]

positive regulation of cyclase activity [inference]

positive regulation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity

regulation of lyase activity [inference]

regulation of adenylate cyclase activity [inference]

positive regulation of adenylate cyclase activity

positive regulation of lyase activity [inference]

positive regulation of adenylate cyclase activity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
membrane	HDA IBA	19946888
plasma membrane raft	IDA	19171672
plasma membrane	IDA	16645049 16921383 19171672 19182790 27185316 28219928 32415068
membrane raft	IDA	22494970
calcium channel complex	ISS	31009446

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

cellular anatomical entity [inference]

membrane

plasma membrane

plasma membrane region [inference]

membrane microdomain [inference]

membrane raft

plasma membrane raft

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	17360584 17442569 17905723 19182790 19249086 19706428 19706554 19887627 20418871 20887894 21408196 21427704 21876174 22451904 22464749 22494970 22586105 23307288 24954132 24996186 27185316 28219928 30481768 30573509 32415068 33941685
calmodulin binding	IEA
store-operated calcium channel activity	IBA IDA	16645049 16733527 16766533 16807233 16921383 17442569 19182790 23307288 26221052 28219928 32415068 33941685
calcium channel activity	IDA	31009446
identical protein binding	IPI	18757751 19249086 20018736 20194792 24996186

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

store-operated calcium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

store-operated calcium channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

store-operated calcium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

store-operated calcium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

store-operated calcium channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

store-operated calcium channel activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Calcium release-activated calcium channel protein 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
store-operated calcium channel activity
store-operated calcium entry

Displaying **all 2** entries
InterPro
Calcium release-activated calcium channel protein
Orai superfamily

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080686	tubular aggregate myopathy 2	Alliance of Genome Resources
DOID:0111976	immunodeficiency 9	Alliance of Genome Resources
DOID:11984	hypertrophic cardiomyopathy	Alliance of Genome Resources
DOID:12930	dilated cardiomyopathy	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 58 in total

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Species	Gene ID	Orthologous MAtrix
Latimeria chalumnae	102365455	LATCH18428
Myotis lucifugus	102418943	MYOLU16031
Pelodiscus sinensis	102446257	PELSI03462
Erinaceus europaeus	103128886	ERIEU10442
Chlorocebus sabaeus	103239286	CHLSB02730
Carlito syrichta	103275064	CARSF29852
Nannospalax galili	103739067	NANGA08004
Rhinopithecus roxellana	104666279	RHIRO00118
Pteropus vampyrus	105289200	PTEVA06538
Mandrillus leucophaeus	105527956	MANLE02693

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GlycoPOST

UniCarb-DR

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements