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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
ORAI calcium release-activated calcium modulator 1
Summary
- Gene Symbol
-
- ORAI1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Adaptive immunity
- Alternative initiation
- Calcium channel
- Calmodulin-binding
- Cell membrane
- Disease variant
- Glycoprotein
- Phosphoprotein
- Reference proteome
- Transmembrane helix
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| Q96D31 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| ion channel modulating, G protein-coupled receptor signaling pathway | ||
| positive regulation of adenylate cyclase activity | ||
| positive regulation of insulin secretion | ||
| calcium ion transmembrane transport | ||
| adaptive immune response |
GO Hierarchy
biological process
| GO Term | Evidence Code | PMID |
|---|---|---|
| basolateral plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| calmodulin binding | ||
| store-operated calcium channel activity | ||
| calcium channel activity | ||
| identical protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Calcium release-activated calcium channel protein 1
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| store-operated calcium channel activity |
| store-operated calcium entry |
| InterPro |
|---|
| Calcium release-activated calcium channel protein |
| Orai superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080686 | tubular aggregate myopathy 2 | |
| DOID:0111976 | immunodeficiency 9 | |
| DOID:11984 | hypertrophic cardiomyopathy | |
| DOID:12930 | dilated cardiomyopathy |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 102365455 | LATCH18428 | |||
| 102418943 | MYOLU16031 | |||
| 102446257 | PELSI03462 | |||
| 103128886 | ERIEU10442 | |||
| 103239286 | CHLSB02730 | |||
| 103275064 | CARSF29852 | |||
| 103739067 | NANGA08004 | |||
| 104666279 | RHIRO00118 | |||
| 105289200 | PTEVA06538 | |||
| 105527956 | MANLE02693 |
