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signal peptide peptidase like 2A

Summary

Gene Symbol

SPPL2A

Organism

Homo sapiens (human)

External Links

NCBI Gene

84888

PubChem

84888

Alliance of Genome Resources

HGNC:30227

Annotation

Keyword

Endosome
Glycoprotein
Hydrolase
Lysosome
Protease
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A8V8TLZ2
Q8TCT8	Intramembrane protease 3 Presenilin-like protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
membrane protein ectodomain proteolysis	IDA	16829951 17965014
regulation of tumor necrosis factor-mediated signaling pathway	TAS
membrane protein intracellular domain proteolysis	IDA	16829951 17557115
membrane protein intracellular domain proteolysis	IMP	16829952
membrane protein proteolysis	IDA	2313285

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of immune response

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
lysosomal membrane	IBA
lysosomal membrane	HDA	17897319
late endosome	IDA	16829952
plasma membrane	TAS
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

late endosome membrane

Golgi-associated vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

Golgi-associated vesicle membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16189514 17965014 25416956 32296183 32814053
aspartic endopeptidase activity, intramembrane cleaving	TAS
aspartic endopeptidase activity, intramembrane cleaving	IDA	2313285
aspartic endopeptidase activity, intramembrane cleaving	IBA
protein homodimerization activity	IDA	15385547

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

aspartic-type peptidase activity [inference]

aspartic-type endopeptidase activity [inference]

aspartic endopeptidase activity, intramembrane cleaving

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

signal peptide peptidase-like

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
aspartic endopeptidase activity, intramembrane cleaving
hydrolase activity
membrane protein proteolysis

Displaying **all 3** entries
InterPro
PA domain
Peptidase A22B, signal peptide peptidase
Presenilin/signal peptide peptidase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:612	primary immunodeficiency disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	56928	WB:WBGene00007979
Mus musculus	66552	Xenbase:XB-GENE-993495	MOUSE33666
Caenorhabditis elegans	73218	WB:WBGene00007979
Xenopus tropicalis	84888	Xenbase:XB-GENE-993495
Caenorhabditis elegans	162540	WB:WBGene00007979
Caenorhabditis elegans	237958	WB:WBGene00007979
Rattus norvegicus	311401		RATNO27401
Caenorhabditis elegans	362828	WB:WBGene00007979
Pan troglodytes	453430		PANTR10311
Canis lupus familiaris	478301		CANLF12511

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OrthoDB (Group)

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Acknowledgements