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signal peptide peptidase like 2A

Summary

Gene Symbol

SPPL2A

Organism

Homo sapiens (human)

External Links

NCBI Gene

84888

KEGG Gene ID

PubChem

84888

Alliance of Genome Resources

HGNC:30227

Annotation

Keyword

Endosome
Glycoprotein
Lysosome
Protease
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A8V8TLZ2	Intramembrane protease 3 Presenilin-like protein 2
Q8TCT8	Intramembrane protease 3 Presenilin-like protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
membrane protein ectodomain proteolysis	IDA
regulation of tumor necrosis factor-mediated signaling pathway	TAS
membrane protein intracellular domain proteolysis	IDA
membrane protein intracellular domain proteolysis	IMP
membrane protein proteolysis	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

membrane protein proteolysis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of immune response

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

regulation of tumor necrosis factor-mediated signaling pathway

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
lysosomal membrane	ISS
lysosomal membrane	IBA
lysosomal membrane	IEA
lysosomal membrane	HDA
late endosome	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

endosome membrane [inference]

late endosome membrane

Golgi-associated vesicle membrane

bounding membrane of organelle

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane [inference]

late endosome membrane

Golgi-associated vesicle membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of endoplasmic reticulum membrane

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
aspartic endopeptidase activity, intramembrane cleaving	TAS
aspartic endopeptidase activity, intramembrane cleaving	IDA
aspartic endopeptidase activity, intramembrane cleaving	IBA
aspartic endopeptidase activity, intramembrane cleaving	IEA