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zinc finger FYVE-type containing 19

Summary

Gene Symbol

ZFYVE19

Organism

Homo sapiens (human)

External Links

NCBI Gene

84936

PubChem

84936

Alliance of Genome Resources

HGNC:20758

Annotation

Keyword

Alternative splicing
Cell division
Chromosomal rearrangement
Ciliopathy
Coiled coil
Cytoskeleton
Disease variant
Intrahepatic cholestasis
Isopeptide bond
Lipid-binding
Phosphoprotein
Proto-oncogene
Reference proteome
Ubl conjugation
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96K21	MLL partner containing FYVE domain Zinc finger FYVE domain-containing protein 19

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
abscission
negative regulation of cytokinesis	IMP	24814515
mitotic cytokinesis checkpoint signaling	IMP	24814515
mitotic cytokinesis checkpoint signaling	IBA
midbody abscission	IMP	24814515

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic cytokinesis checkpoint signaling

cell cycle process [inference]

cytokinetic process [inference]

mitotic cytokinetic process [inference]

midbody abscission

mitotic cell cycle process [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic cytokinesis checkpoint signaling

mitotic cytokinetic process [inference]

midbody abscission

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

midbody abscission

developmental process [inference]

abscission

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cytokinesis

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of cell division [inference]

negative regulation of cytokinesis

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cytokinesis

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of cell division [inference]

negative regulation of cytokinesis

regulation of cell division [inference]

regulation of cytokinesis [inference]

negative regulation of cytokinesis

negative regulation of cell division [inference]

negative regulation of cytokinesis

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of cytokinesis

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

regulation of cytokinesis [inference]

negative regulation of cytokinesis

regulation of cell cycle phase transition [inference]

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

regulation of mitotic cell cycle phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

regulation of cell cycle G2/M phase transition [inference]

regulation of G2/M transition of mitotic cell cycle [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of cytokinesis

negative regulation of cell cycle phase transition [inference]

cell cycle checkpoint signaling [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of cell cycle G2/M phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle [inference]

mitotic cell cycle checkpoint signaling [inference]

mitotic cytokinesis checkpoint signaling

negative regulation of mitotic cell cycle phase transition [inference]

negative regulation of G2/M transition of mitotic cell cycle [inference]

mitotic cytokinesis checkpoint signaling

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
centrosome	IDA	24814515
centrosome	IBA
midbody	IDA	24814515
midbody	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

microtubule organizing center [inference]

centrosome

membrane [inference]

plasma membrane region [inference]

cleavage furrow

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	17500595 23275563 24814515 25416956 26871637 31515488 32296183 32814053
zinc ion binding	IEA
phosphatidylinositol-3-phosphate binding	IDA	24814515
phosphatidylinositol-3-phosphate binding	IBA
metal ion binding

GO Hierarchy

molecular function

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol-3-phosphate binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

zinc finger FYVE domain containing 19

Functional Category

M: Cell wall/membrane/envelope biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
abscission
metal ion binding
phosphatidylinositol-3-phosphate binding

Displaying **all 5** entries
InterPro
ANCHR, B-box-type 1 zinc finger domain
FYVE zinc finger
Zinc finger, FYVE-related
Zinc finger, FYVE/PHD-type
Zinc finger, RING/FYVE/PHD-type

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070221	progressive familial intrahepatic cholestasis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	72008		MOUSE36035
Xenopus tropicalis	84936	Xenbase:XB-GENE-1013586
Danio rerio	436685		DANRE13287
Rattus norvegicus	499871		RATNO26588
Bos taurus	511054		BOVIN01036
Monodelphis domestica	100032031		MONDO02331
Ornithorhynchus anatinus	100089202		ORNAN04456
Ciona intestinalis	100170072		CIOIN03849
Pongo abelii	100174515		PONAB09499
Taeniopygia guttata	100220030		TAEGU26282