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PTPRF interacting protein alpha 1

Summary

Gene Symbol

PPFIA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

8500

PubChem

8500

Alliance of Genome Resources

HGNC:9245

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Cytoplasm
Phosphoprotein
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B3KVS8
Q13136	LAR-interacting protein 1 Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cell-matrix adhesion	TAS	7796809
signal transduction	TAS	7796809
cortical microtubule organization	IMP	24120883
synapse organization	IBA
negative regulation of stress fiber assembly	IMP	22266902

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

cytoplasmic microtubule organization [inference]

cortical microtubule organization

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization [inference]

cytoplasmic microtubule organization [inference]

cortical microtubule organization

cortical cytoskeleton organization [inference]

cortical microtubule organization

cell junction organization [inference]

synapse organization

supramolecular fiber organization [inference]

cytoplasmic microtubule organization [inference]

cortical microtubule organization

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular process [inference]

signal transduction

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actomyosin structure organization [inference]

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of stress fiber assembly [inference]

negative regulation of stress fiber assembly

negative regulation of supramolecular fiber organization [inference]

negative regulation of actin filament bundle assembly [inference]

negative regulation of stress fiber assembly

regulation of cellular localization [inference]

regulation of protein localization [inference]

negative regulation of protein localization [inference]

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to cell periphery [inference]

negative regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane [inference]

negative regulation of protein localization to plasma membrane

negative regulation of protein localization to membrane [inference]

negative regulation of protein localization to plasma membrane

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cytoplasm	TAS	7796809
cytosol	TAS
cytosol	IDA
focal adhesion	IDA
cell cortex	IDA	24120883

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

cytoplasm

cell cortex

cytosol

cell junction [inference]

synapse [inference]

Schaffer collateral - CA1 synapse

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

spine apparatus

presynaptic active zone

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	11931740 12923177 16189514 19060904 25416956 26496610 29892012 31515488 32296183 33961781

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

liprin-alpha

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
synapse organization

Displaying **all 6** entries
InterPro
LAR-interacting protein, Liprin
Liprin-alpha, SAM domain repeat 1
Liprin-alpha, SAM domain repeat 2
Liprin-alpha, SAM domain repeat 3
Sterile alpha motif domain
Sterile alpha motif/pointed domain superfamily

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	8497	FB:FBgn0046704
Drosophila melanogaster	8499	FB:FBgn0046704
Xenopus tropicalis	8500	Xenbase:XB-GENE-984553
Drosophila melanogaster	8541	FB:FBgn0046704
Drosophila melanogaster	76787	FB:FBgn0046704
Mus musculus	233977		MOUSE51335
Rattus norvegicus	293645		RATNO20310
Drosophila melanogaster	327814	FB:FBgn0046704
Pan troglodytes	451390		PANTR03670
Canis lupus familiaris	475999		CANLF05941