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peroxisomal biogenesis factor 3

Summary

Gene Symbol

PEX3

Organism

Homo sapiens (human)

External Links

NCBI Gene

8504

PubChem

8504

Alliance of Genome Resources

HGNC:8858

Annotation

Keyword

3D-structure
Disease variant
Peroxisome
Peroxisome biogenesis
Reference proteome
Transmembrane helix
Zellweger syndrome

Proteins

Displaying 1 entry
UniProt	Protein Name
P56589	Peroxin-3 Peroxisomal assembly protein PEX3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein import into peroxisome membrane	IBA IMP	15007061
peroxisome organization	IMP	10958759 12924628 18174172 19479899

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

peroxisome organization

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome membrane

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome membrane

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

protein import into peroxisome membrane

localization within membrane [inference]

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

protein localization to peroxisome [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into peroxisome membrane

establishment of protein localization to organelle [inference]

establishment of protein localization to peroxisome [inference]

protein import into peroxisome membrane

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

protein localization to membrane [inference]

establishment of protein localization to membrane [inference]

protein import into peroxisome membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
membrane	HDA	19946888
peroxisome	IDA IMP	12924628 9922452
protein-containing complex	IDA	18174172
nucleoplasm	IDA
protein-lipid complex	IDA	19715730

GO Hierarchy

cellular component

protein-containing complex

protein-lipid complex

cellular anatomical entity [inference]

nucleoplasm

organelle membrane [inference]

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10704444 11883941 12096124 16189514 16280322 18174172 19715730 21102411 25416956 25502805 27107012 28514442 29997244 31467278 31515488 32296183 32814053 33961781 35271311 37398436 38225382
protein-macromolecule adaptor activity	IBA
lipid binding	IDA	19715730

GO Hierarchy

molecular function

binding [inference]

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Peroxisomal biogenesis factor 3

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
peroxisome organization
protein import into peroxisome membrane
protein-macromolecule adaptor activity

Displaying 1 entry
InterPro
Peroxin-3

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080484	peroxisome biogenesis disorder 10A	Alliance of Genome Resources
DOID:0081440	Peroxisome biogenesis disorder 10B	Alliance of Genome Resources
DOID:905	Zellweger syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	39652		FB:FBgn0036484
Mus musculus	56535		MGI:1929646	MOUSE01979
Rattus norvegicus	83519		RGD:621636	RATNO17124
Danio rerio	393197		ZFIN:ZDB-GENE-040426-979	DANRE20155
Xenopus laevis	444067		Xenbase:XB-GENE-6256248
Pan troglodytes	463038	9598_0:001f2f		PANTR39221
Canis lupus familiaris	484015			CANLF00171
Bos taurus	515730			BOVIN35912
Macaca mulatta	700730			MACMU33498
Xenopus tropicalis	733783		Xenbase:XB-GENE-954958

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024