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malate dehydrogenase MDH3

Summary

Gene Symbol

MDH3

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

851481

PubChem

851481

Alliance of Genome Resources

SGD:S000002236

Annotation

Keyword

3D-structure
Direct protein sequencing
Glyoxylate bypass
NAD
Oxidoreductase
Peroxisome
Reference proteome
Tricarboxylic acid cycle

Proteins

Displaying 1 entry
UniProt	Protein Name
P32419

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
malate metabolic process	IEA
glyoxylate cycle	IEA
NADH regeneration	IMP	7628449
fatty acid beta-oxidation	IMP	7628449
tricarboxylic acid cycle	IBA IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid oxidation [inference]

fatty acid beta-oxidation

glyoxylate metabolic process [inference]

glyoxylate cycle

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

dicarboxylic acid metabolic process [inference]

malate metabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid oxidation [inference]

fatty acid beta-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

primary metabolic process [inference]

carbohydrate metabolic process [inference]

glyoxylate cycle

tricarboxylic acid cycle

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid oxidation [inference]

fatty acid beta-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid oxidation [inference]

fatty acid beta-oxidation

glyoxylate metabolic process [inference]

glyoxylate cycle

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

dicarboxylic acid metabolic process [inference]

malate metabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

glyoxylate cycle

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid oxidation [inference]

fatty acid beta-oxidation

glyoxylate metabolic process [inference]

glyoxylate cycle

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

dicarboxylic acid metabolic process [inference]

malate metabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid oxidation [inference]

fatty acid beta-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

organonitrogen compound metabolic process [inference]

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

glyoxylate metabolic process [inference]

glyoxylate cycle

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid oxidation [inference]

fatty acid beta-oxidation

glyoxylate metabolic process [inference]

glyoxylate cycle

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

dicarboxylic acid metabolic process [inference]

malate metabolic process

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

fatty acid oxidation [inference]

fatty acid beta-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

fatty acid beta-oxidation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

pyridine-containing compound metabolic process [inference]

pyridine nucleotide metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD metabolic process [inference]

NADH metabolic process [inference]

NADH regeneration

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytoplasm	IBA
peroxisome	IDA IEA	1447211 7628449
mitochondrion	IBA
peroxisomal matrix	IDA	8824293

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
oxidoreductase activity	IEA
L-malate dehydrogenase activity	IBA IDA IEA IMP	1447211 1986231 7628449
mRNA binding	IDA	21124907

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

malate dehydrogenase activity [inference]

L-malate dehydrogenase activity

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

L-malate dehydrogenase activity

binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

mRNA binding

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
peroxisomal matrix	PMID:8824293
peroxisome	PMID:1447211 PMID:7628449

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:2316	brain ischemia	Alliance of Genome Resources
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	175936	WB:WBGene00003162
Drosophila melanogaster	39469	FB:FBgn0036327
Drosophila melanogaster	42185	FB:FBgn0262559
Danio rerio	406405	ZFIN:ZDB-GENE-040426-2143
Mus musculus	17448	MGI:97050
Rattus norvegicus	81829	RGD:619719

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024