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Guidelines

MIRAGE

DNA-directed DNA polymerase eta

Summary

Gene Symbol

RAD30

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852028

PubChem

852028

Alliance of Genome Resources

SGD:S000002827

Annotation

Keyword

3D-structure
DNA repair
DNA replication
DNA synthesis
DNA-binding
DNA-directed DNA polymerase
Magnesium
Mutator protein
Nucleus
Reference proteome
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q04049	Radiation-sensitive protein 30

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

1

2

3

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GO Term	Evidence Code	PMID
DNA replication	IEA
DNA repair	IEA
chromosome segregation	IMP	23326240
mitotic sister chromatid cohesion	IMP	23326240
response to radiation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular process [inference]

cell cycle process [inference]

chromosome segregation

sister chromatid cohesion [inference]

mitotic sister chromatid cohesion

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

postreplication repair [inference]

translesion synthesis [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

sister chromatid cohesion [inference]

mitotic sister chromatid cohesion

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

postreplication repair [inference]

translesion synthesis [inference]

response to abiotic stimulus [inference]

response to radiation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

postreplication repair [inference]

translesion synthesis [inference]

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
nucleus	IDA	23313845
nucleus	IBA
nucleus	IEA
replication fork	IBA
replication fork	IPI	11545742

GO Hierarchy

cellular component

cellular anatomical entity [inference]

replication fork

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

site of DNA damage [inference]

site of double-strand break

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
DNA binding	IEA
damaged DNA binding	IEA
DNA-directed DNA polymerase activity	IDA	10601233 9974380
DNA-directed DNA polymerase activity	IBA
DNA-directed DNA polymerase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity

DNA-directed DNA polymerase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA polymerase activity

DNA-directed DNA polymerase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

damaged DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA polymerase

Functional Category

C: Energy production and conversion
L: Replication, recombination and repair

Displaying **all 6** entries
Gene Ontology
DNA repair
damaged DNA binding
error-prone translesion synthesis
metal ion binding
response to radiation
transferase activity

Displaying **all 6** entries
InterPro
DNA polymerase eta, ubiquitin-binding zinc finger
DNA polymerase, Y-family, little finger domain superfamily
DNA polymerase, Y-family, little finger domain
DNA/RNA polymerase superfamily
Reverse transcriptase/Diguanylate cyclase domain
UmuC domain

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
nucleus	PMID:23313845
mitochondrion	PMID:23313845
replication fork	PMID:11545742

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050427	xeroderma pigmentosum	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	5429	ZFIN:ZDB-GENE-060421-4949
Xenopus tropicalis	852028	Xenbase:XB-GENE-943046

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025