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DNA-directed DNA polymerase eta

Summary

Gene Symbol

RAD30

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852028

PubChem

852028

Alliance of Genome Resources

SGD:S000002827

Annotation

Keyword

3D-structure
DNA repair
DNA replication
DNA synthesis
DNA-binding
DNA-directed DNA polymerase
Magnesium
Mutator protein
Nucleus
Reference proteome
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q04049	Radiation-sensitive protein 30

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
DNA replication	IEA
DNA repair	IEA
error-free translesion synthesis	IDA IEA	10713149 10932195 11027270 9974380
chromosome segregation	IMP	23326240
DNA biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular process [inference]

cell cycle process [inference]

chromosome segregation

sister chromatid cohesion [inference]

mitotic sister chromatid cohesion

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

sister chromatid cohesion [inference]

mitotic sister chromatid cohesion

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

response to abiotic stimulus [inference]

response to radiation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
site of double-strand break	IBA
intracellular membrane-bounded organelle	IEA
mitochondrion	IDA	23313845
nucleus	IBA IDA IEA	23313845
replication fork	IBA IPI	11545742

GO Hierarchy

cellular component

cellular anatomical entity [inference]

replication fork

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

site of DNA damage [inference]

site of double-strand break

Displaying **all 5** entries
GO Term	Evidence Code	PMID
zinc ion binding	RCA	30358795
DNA binding	IEA
metal ion binding	IEA
DNA-directed DNA polymerase activity	IBA IDA IEA	10601233 9974380
damaged DNA binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

damaged DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dna polymerase

Functional Category

C: Energy production and conversion
L: Replication, recombination and repair

Displaying **all 6** entries
Gene Ontology
DNA repair
damaged DNA binding
error-prone translesion synthesis
metal ion binding
response to radiation
transferase activity

Displaying **all 6** entries
InterPro
DNA polymerase eta, ubiquitin-binding zinc finger
DNA polymerase, Y-family, little finger domain superfamily
DNA polymerase, Y-family, little finger domain
DNA/RNA polymerase superfamily
Reverse transcriptase/Diguanylate cyclase domain
UmuC domain

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
nucleus	PMID:23313845
mitochondrion	PMID:23313845
replication fork	PMID:11545742

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050427	xeroderma pigmentosum	Alliance of Genome Resources
DOID:0050671	female breast cancer	Alliance of Genome Resources
DOID:0110847	xeroderma pigmentosum variant type	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 28 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	5429		HGNC:9181
Drosophila melanogaster	40438		FB:FBgn0037141
Mus musculus	80905		MGI:1891457
Caenorhabditis elegans	175337		WB:WBGene00018721
Rattus norvegicus	316235		RGD:1309893
Xenopus tropicalis	613070		Xenbase:XB-GENE-943046
Danio rerio	678520		ZFIN:ZDB-GENE-060421-4949
Kluyveromyces lactis	2896756	28985_0:00009e
Eremothecium gossypii ATCC 10895	4618631	284811_0:00011a
Vanderwaltozyma polyspora DSM 70294	5543242	436907_0:000383

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UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements