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pyruvate carboxylase 2

Summary

Gene Symbol

PYC2

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852519

PubChem

852519

Alliance of Genome Resources

SGD:S000000422

Annotation

Keyword

ATP-binding
Acetylation
Biotin
Cytoplasm
Gluconeogenesis
Ligase
Metal-binding
Multifunctional enzyme
Reference proteome
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
P32327	Pyruvic carboxylase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
small molecule biosynthetic process	IEA
gluconeogenesis	IBA IEA IMP	8185321
pyruvate metabolic process	IBA IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

small molecule biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

glucose metabolic process [inference]

gluconeogenesis

hexose biosynthetic process [inference]

gluconeogenesis

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

organic substance biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

gluconeogenesis

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	IDA	196563 2665820
cytoplasm	IBA IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
zinc ion binding	RCA	30358795
metal ion binding	IEA
pyruvate carboxylase activity	IBA IEA IMP	2039506
ATP binding	IEA
ligase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity

ligase activity, forming carbon-carbon bonds [inference]

pyruvate carboxylase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

carboxylase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 4** entries
Gene Ontology
ATP binding
ligase activity
metal ion binding
nucleotide binding

Displaying **all 9** entries
InterPro
ATP-grasp fold
Biotin carboxylase, C-terminal
Biotin carboxylase-like, N-terminal domain
Biotin carboxylation domain
Biotin/lipoyl attachment
Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
Pre-ATP-grasp domain superfamily
Rudiment single hybrid motif
Single hybrid motif

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cytosol	PMID:196563 PMID:2665820

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:3649	pyruvate decarboxylase deficiency	Alliance of Genome Resources
DOID:3651	pyruvate carboxylase deficiency disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 40 in total

1

2

3

4

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5091		HGNC:8636
Mus musculus	18563		MGI:97520
Rattus norvegicus	25104		RGD:3262
Drosophila melanogaster	36020		FB:FBgn0027580
Danio rerio	58068		ZFIN:ZDB-GENE-000831-1
Caenorhabditis elegans	179616		WB:WBGene00004258
Danio rerio	553283		ZFIN:ZDB-GENE-090908-3
Kluyveromyces lactis	2892373	28985_0:0006ea
Eremothecium gossypii ATCC 10895	4618741	284811_0:000172
Vanderwaltozyma polyspora DSM 70294	5543330	436907_0:0003cf

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024