GlyCosmos Portal

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Glycosidase
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P38138	Alpha-glucosidase II subunit alpha Glucosidase II subunit alpha Reversal of TOR2 lethality protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
polysaccharide biosynthetic process
N-glycan processing	IBA IMP	16373354
fungal-type cell wall beta-glucan biosynthetic process	IGI	9430631
carbohydrate metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide metabolic process [inference]

cell wall beta-glucan metabolic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall beta-glucan metabolic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide metabolic process [inference]

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall beta-glucan metabolic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

glucan metabolic process [inference]

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

beta-glucan metabolic process [inference]

cell wall beta-glucan metabolic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall beta-glucan metabolic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

organic substance metabolic process [inference]

carbohydrate metabolic process

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide metabolic process [inference]

cell wall beta-glucan metabolic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall beta-glucan metabolic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide metabolic process [inference]

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall beta-glucan metabolic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

glucan metabolic process [inference]

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

beta-glucan metabolic process [inference]

cell wall beta-glucan metabolic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall beta-glucan metabolic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide metabolic process [inference]

cell wall beta-glucan metabolic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall beta-glucan metabolic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide metabolic process [inference]

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall beta-glucan metabolic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

glucan metabolic process [inference]

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

beta-glucan metabolic process [inference]

cell wall beta-glucan metabolic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall beta-glucan metabolic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

cell wall macromolecule metabolic process [inference]

cell wall polysaccharide metabolic process [inference]

cell wall beta-glucan metabolic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall beta-glucan metabolic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide metabolic process [inference]

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall beta-glucan metabolic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

N-glycan processing

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process

glucan biosynthetic process [inference]

beta-glucan biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

cell wall polysaccharide biosynthetic process [inference]

cell wall beta-glucan biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

fungal-type cell wall polysaccharide biosynthetic process [inference]

fungal-type cell wall beta-glucan biosynthetic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	IDA	16373354
glucosidase II complex	IBA IPI	16373354
mitochondrion	HDA	14576278 16823961
endoplasmic reticulum	HDA IEA	26928762

GO Hierarchy

cellular component

protein-containing complex [inference]

endoplasmic reticulum protein-containing complex [inference]

glucosidase II complex

catalytic complex [inference]

glucosidase II complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
Glc2Man9GlcNAc2 oligosaccharide glucosidase activity	IEA IMP	8910335
hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
alpha-glucosidase activity	IBA
hydrolase activity, acting on glycosyl bonds	IEA
glucan 1,3-alpha-glucosidase activity	IMP	16373354

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing O-glycosyl compounds

glucosidase activity [inference]

Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [inference]

Glc2Man9GlcNAc2 oligosaccharide glucosidase activity

alpha-glucosidase activity

alpha-1,3-glucosidase activity [inference]

glucan 1,3-alpha-glucosidase activity

binding [inference]

carbohydrate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha-glucosidase

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
catalytic activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity

Displaying **all 6** entries
InterPro
Galactose mutarotase-like domain superfamily
Glycoside hydrolase family 31, N-terminal domain
Glycoside hydrolase family 31, TIM barrel domain
Glycoside hydrolase superfamily
Glycosyl hydrolase family 31, C-terminal domain
Glycosyl hydrolase, all-beta

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
endoplasmic reticulum	PMID:26928762
mitochondrion	PMID:14576278 PMID:16823961
endoplasmic reticulum lumen	PMID:16373354
glucosidase II complex	PMID:16373354

Rhea

RHEA:56000

H₂O

β-D-glucose

Enzyme

3.2.1.207

PMID

RHEA:55996

H₂O

β-D-glucose

Enzyme

3.2.1.207

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050770	polycystic liver disease	Alliance of Genome Resources
DOID:0080322	polycystic kidney disease	Alliance of Genome Resources
DOID:0110860	polycystic kidney disease 3	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP007070
Gene Name: glucan 1,3-alpha-glucosidase ROT2

Ortholog

Displaying entries **1 - 10** of 38 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	2595		HGNC:4139
Mus musculus	14376		MGI:1097667
Homo sapiens	23193		HGNC:4138
Rattus norvegicus	24382		RGD:2660
Drosophila melanogaster	49953		FB:FBgn0027588
Mus musculus	76051		MGI:1923301
Caenorhabditis elegans	179364		WB:WBGene00009583
Caenorhabditis elegans	180400		WB:WBGene00018682
Rattus norvegicus	293721		RGD:1309775
Kluyveromyces lactis	2894960	28985_0:00103d

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements