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Guidelines

MIRAGE

imidazoleglycerol-phosphate synthase

Summary

Gene Symbol

HIS7

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852550

PubChem

852550

Alliance of Genome Resources

SGD:S000000452

Annotation

Keyword

3D-structure
Glutamine amidotransferase
Histidine biosynthesis
Hydrolase
Lyase
Multifunctional enzyme
Reference proteome
Stress response

Proteins

Displaying 1 entry
UniProt	Protein Name
P33734

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
histidine biosynthetic process	IMP	14190241
glutamine metabolic process
small molecule metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

small molecule metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

histidine metabolic process [inference]

histidine biosynthetic process

amino acid biosynthetic process [inference]

histidine biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamine metabolic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

histidine biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
cytoplasm	IC	14190241

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
imidazoleglycerol-phosphate synthase activity	IDA	10733892
imidazoleglycerol-phosphate synthase activity	IBA
imidazoleglycerol-phosphate synthase activity	IEA
glutaminase activity	IDA	10733892
glutaminase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

pentosyltransferase activity [inference]

imidazoleglycerol-phosphate synthase activity

hydrolase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

glutaminase activity

carbon-carbon lyase activity [inference]

oxo-acid-lyase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Imidazole glycerol phosphate synthase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis

Displaying entries **1 - 10** of 11 in total

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Gene Ontology
amino acid biosynthetic process
catalytic activity
glutaminase activity
glutamine metabolic process
histidine biosynthetic process
hydrolase activity
imidazoleglycerol-phosphate synthase activity
lyase activity
oxo-acid-lyase activity
pentosyltransferase activity

Displaying **all 8** entries
InterPro
Aldolase-type TIM barrel
Class I glutamine amidotransferase-like
Glutamine amidotransferase
Histidine biosynthesis protein
Histidine biosynthesis, HisF
Imidazole glycerol phosphate synthase HisHF
Imidazole glycerol phosphate synthase, subunit H
Ribulose-phosphate binding barrel

Rhea

L-glutamine + 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamide

H⁺ + L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamide

Enzyme

4.3.2.10

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP007356
Gene Name: imidazoleglycerol-phosphate synthase

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.2.1

Last updated: April 7, 2025