GlyCosmos Portal

Submissions

translation initiation factor eIF4G

Summary

Gene Symbol

TIF4632

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852833

PubChem

852833

Alliance of Genome Resources

SGD:S000003017

Annotation

Keyword

Cytoplasm
Initiation factor
Phosphoprotein
RNA-binding
Reference proteome
Translation regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
P39936	Translation initiation factor 4(4)-F(6) subunit gamma(3) protein 2 eIF4G2 mRNA cap-binding protein complex subunit p130

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
translational initiation	IBA IDA IEA IMP	22851688
translation	IEA
positive regulation of formation of translation preinitiation complex	ISS	30281017
stress granule assembly	IMP	18981231
regulation of translation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular metabolic process [inference]

translational initiation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

primary metabolic process [inference]

protein metabolic process [inference]

translation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular metabolic process [inference]

translational initiation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

stress granule assembly

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

stress granule assembly

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of protein metabolic process [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of protein metabolic process [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasmic stress granule	HDA IDA	17908917 18981231 19470581 26777405
ribosome
P-body	IDA	23222640
eukaryotic translation initiation factor 4F complex	IBA IMP	8336723
cytoplasm	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

RNA cap binding complex [inference]

eukaryotic translation initiation factor 4F complex

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribosome

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribosome

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
protein binding	IPI	12861028
translation initiation factor binding	IDA IMP IPI	12861028 22851688
translation initiation factor activity	IBA IDA IEA IMP	22851688
mRNA binding	HDA IBA IDA	22851688 23222640
ATPase activator activity	ISS	18606994 21062831 24080224

GO Hierarchy

molecular function

binding [inference]

protein binding

translation initiation factor binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

mRNA binding

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

molecular function regulator activity [inference]

ATPase regulator activity [inference]

ATPase activator activity

molecular function activator activity [inference]

ATPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

eukaryotic translation initiation factor 4 gamma

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Armadillo-type fold
Initiation factor 4G
MIF4G-like, type 3

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
cytoplasmic stress granule	PMID:17908917 PMID:18981231 PMID:19470581 PMID:26777405
P-body	PMID:23222640

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060892	late onset Parkinson's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:1591	renovascular hypertension	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 48 in total

1

2

3

4

5

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	1981	HGNC:3296
Homo sapiens	1982	HGNC:3297
Homo sapiens	8672	HGNC:3298
Mus musculus	13690	MGI:109207
Drosophila melanogaster	46020	FB:FBgn0010488
Caenorhabditis elegans	174322	WB:WBGene00002066
Mus musculus	208643	MGI:2384784
Mus musculus	230861	MGI:1923935
Rattus norvegicus	287986	RGD:1306144
Rattus norvegicus	298573	RGD:1311370

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements