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mitogen-activated protein kinase kinase PBS2

Summary

Gene Symbol

PBS2

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

853313

PubChem

853313

Alliance of Genome Resources

SGD:S000003664

Annotation

Keyword

3D-structure
ATP-binding
Antibiotic resistance
Cytoplasm
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase
Tyrosine-protein kinase

Proteins

Displaying 1 entry
UniProt	Protein Name
P08018	Polymyxin B resistance protein 2 Suppressor of fluoride sensitivity 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
phosphorylation	IEA
osmosensory signaling pathway via Sho1 osmosensor	IPI	15200958
p38MAPK cascade	IGI IMP	15707964 7624781
hyperosmotic response	IMP	7681220
actin filament organization	IMP	7941729

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

stress-activated MAPK cascade [inference]

p38MAPK cascade

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

p38MAPK cascade

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation

protein phosphorylation

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

p38MAPK cascade

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization [inference]

actin filament organization

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

hyperosmotic response

cellular hyperosmotic response

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

p38MAPK cascade

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hyperosmotic response

cellular hyperosmotic response

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

response to chemical [inference]

response to antibiotic

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to stimulus [inference]

cellular response to stress [inference]

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

p38MAPK cascade

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

cellular hyperosmotic response

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

MAPK cascade

stress-activated MAPK cascade [inference]

p38MAPK cascade

osmosensory signaling pathway

osmosensory signaling pathway via Sho1 osmosensor

stress-activated protein kinase signaling cascade [inference]

stress-activated MAPK cascade [inference]

p38MAPK cascade

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasmic stress granule	HDA	26777405
cellular bud neck	IDA	10980703
cellular bud tip	IDA	10980703
cytoplasm	IDA IEA	9755161
NatB complex

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

protein acetyltransferase complex [inference]

N-terminal protein acetyltransferase complex [inference]

NatB complex

catalytic complex [inference]

transferase complex [inference]

acetyltransferase complex [inference]

protein acetyltransferase complex [inference]

N-terminal protein acetyltransferase complex [inference]

NatB complex

cellular anatomical entity [inference]

cytoplasm

site of polarized growth [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	14685261
protein serine kinase activity	IEA
protein serine/threonine kinase activity	IEA
protein tyrosine kinase activity	IEA
MAP kinase kinase activity	IBA IEA IMP ISS	7624781 7681220

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

acetyltransferase activity [inference]

N-acetyltransferase activity [inference]

peptide N-acetyltransferase activity [inference]

peptide alpha-N-acetyltransferase activity

N-acyltransferase activity [inference]

N-acetyltransferase activity [inference]

peptide N-acetyltransferase activity [inference]

peptide alpha-N-acetyltransferase activity

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity [inference]

MAP kinase kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity [inference]

MAP kinase kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

protein serine/threonine/tyrosine kinase activity [inference]

MAP kinase kinase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity [inference]

MAP-kinase scaffold activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

kinase kinase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation
transferase activity

Displaying **all 4** entries
InterPro
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
cellular bud neck	PMID:10980703
cellular bud tip	PMID:10980703
cytoplasm	PMID:9755161
cytoplasmic stress granule	PMID:26777405

Disease

Disease Ontology

Displaying entries **1 - 10** of 32 in total

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DO ID	Disease Name	Source
DOID:0050865	tongue squamous cell carcinoma	Alliance of Genome Resources
DOID:0050933	ovarian serous carcinoma	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:11870	Pick's disease	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:1612	breast cancer	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:219	colon cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 47 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	5606	HGNC:6843
Homo sapiens	5607	HGNC:6845
Homo sapiens	5608	HGNC:6846
Homo sapiens	5609	HGNC:6847
Homo sapiens	6416	HGNC:6844
Mus musculus	23938	MGI:1346345
Mus musculus	26397	MGI:1346868
Mus musculus	26398	MGI:1346869
Mus musculus	26399	MGI:1346870
Mus musculus	26400	MGI:1346871

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements