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dolichyl-phosphate-mannose-protein mannosyltransferase

Summary

Gene Symbol

PMT4

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

853608

KEGG Gene ID

sce:YJR143C

PubChem

853608

Alliance of Genome Resources

SGD:S000003904

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Reference proteome
Repeat
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P46971

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein O-linked glycosylation	IEA IMP	8585318
protein glycosylation	IEA
fungal-type cell wall biogenesis
regulation of endoplasmic reticulum unfolded protein response	IGI	21231968
protein O-linked mannosylation	IBA IMP	18182384 21231968

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

mannosylation [inference]

protein mannosylation [inference]

protein O-linked mannosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule glycosylation [inference]

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation

protein O-linked glycosylation

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

cellular process [inference]

cell wall organization or biogenesis [inference]

cell wall biogenesis [inference]

fungal-type cell wall biogenesis

fungal-type cell wall organization or biogenesis [inference]

fungal-type cell wall biogenesis

cellular component organization or biogenesis [inference]

cellular component biogenesis [inference]

cell wall biogenesis [inference]

fungal-type cell wall biogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of endoplasmic reticulum unfolded protein response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of endoplasmic reticulum unfolded protein response

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of endoplasmic reticulum unfolded protein response

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	IEA
dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex	IPI	12551906
endoplasmic reticulum membrane	IEA
endoplasmic reticulum	HDA IBA IEA	26928762

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase complex [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex

endoplasmic reticulum protein-containing complex [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase complex [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex

intracellular protein-containing complex [inference]

mannosyltransferase complex [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase complex [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex

catalytic complex [inference]

transferase complex [inference]

mannosyltransferase complex [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase complex [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mannosyltransferase activity	IEA
identical protein binding
dolichyl-phosphate-mannose-protein mannosyltransferase activity	IBA IDA IEA IMP	21956107 8585318
glycosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity

hexosyltransferase activity [inference]

mannosyltransferase activity

dolichyl-phosphate-mannose-protein mannosyltransferase activity

catalytic activity, acting on a protein [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase activity

binding [inference]

protein binding [inference]

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

mannosyltransferase

Functional Category

H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
dolichyl-phosphate-mannose-protein mannosyltransferase activity
mannosyltransferase activity
protein O-linked glycosylation
protein O-linked mannosylation
transferase activity

Displaying **all 5** entries
InterPro
Glycosyl transferase family 39/83
Glycosyltransferase 39-like
MIR motif
Mir domain superfamily
Protein O-mannosyl-transferase, C-terminal four TM domain

KEGG BRITE Database

Orthology

K00728

Name

dolichyl-phosphate-mannose-protein mannosyltransferase [EC:2.4.1.109]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R07620	2.4.1.109	G74840NI	G61491DK

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex	PMID:12551906
endoplasmic reticulum	PMID:26928762

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0050453	lissencephaly	Alliance of Genome Resources
DOID:0050560	Walker-Warburg syndrome	Alliance of Genome Resources
DOID:0050588	muscular dystrophy-dystroglycanopathy type B1	Alliance of Genome Resources
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:0110297	autosomal recessive limb-girdle muscular dystrophy type 2K	Alliance of Genome Resources
DOID:0111237	congenital muscular dystrophy-dystroglycanopathy type A1	Alliance of Genome Resources
DOID:0112374	muscular dystrophy-dystroglycanopathy	Alliance of Genome Resources
DOID:9296	cleft lip	Alliance of Genome Resources
DOID:9884	muscular dystrophy	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP007101
Gene Name: Pmt4p

Ortholog

Displaying entries **1 - 10** of 29 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	10585		HGNC:9202
Drosophila melanogaster	39297		FB:FBgn0003292
Rattus norvegicus	84430		RGD:620078
Mus musculus	99011		MGI:2138994
Xenopus tropicalis	448433		Xenbase:XB-GENE-944435
Danio rerio	569769		ZFIN:ZDB-GENE-060929-966
Kluyveromyces lactis	2897519	28985_0:0002d1
Eremothecium gossypii ATCC 10895	4618943	284811_0:0002b7
Vanderwaltozyma polyspora DSM 70294	5543796	436907_0:000575
Zygosaccharomyces rouxii	8202488	4956_0:00036a

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements