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Guidelines

MIRAGE

dynamin-like GTPase VPS1

Summary

Gene Symbol

VPS1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

853870

PubChem

853870

Alliance of Genome Resources

SGD:S000001709

Annotation

Keyword

Cell division
Cytoskeleton
GTP-binding
Meiosis
Microtubule
Motor protein
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P21576

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
autophagosome assembly	IMP	37060997
mitochondrial fission	IBA
protein targeting to vacuole	IMP	8299420
endocytosis	IMP	20841380 26478779
endocytosis	IGI	20841380

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular process [inference]

cell cycle [inference]

meiotic cell cycle

vesicle-mediated transport [inference]

endocytosis

actin filament-based process [inference]

actin cytoskeleton organization

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cell division

cellular localization [inference]

intracellular transport [inference]

vacuolar transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

protein localization to phagophore assembly site

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

protein retention in Golgi apparatus

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

mitochondrial fission

mitochondrion distribution [inference]

intracellular distribution of mitochondria

cytoskeleton organization [inference]

actin cytoskeleton organization

peroxisome organization

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle fission [inference]

organelle assembly [inference]

autophagosome assembly

cellular component assembly [inference]

actin filament bundle assembly

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

lipid tube assembly

organelle assembly [inference]

autophagosome assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-lipid complex assembly [inference]

lipid tube assembly

protein-lipid complex organization [inference]

protein-lipid complex assembly [inference]

lipid tube assembly

supramolecular fiber organization [inference]

actin filament organization [inference]

actin filament bundle organization [inference]

actin filament bundle assembly

reproductive process [inference]

meiotic cell cycle

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

protein localization to phagophore assembly site

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

intracellular transport [inference]

vacuolar transport

import into cell [inference]

endocytosis

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

establishment of localization in cell [inference]

intracellular transport [inference]

vacuolar transport

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in cell [inference]

protein retention in Golgi apparatus

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

protein retention in Golgi apparatus

organelle localization [inference]

mitochondrion localization [inference]

mitochondrion distribution [inference]

intracellular distribution of mitochondria

cellular localization [inference]

intracellular transport [inference]

vacuolar transport

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

protein localization to phagophore assembly site

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
fungal-type vacuole membrane	IDA	15550248
phagophore assembly site	IMP	37060997
cytoplasm	IBA
cytoplasm	IEA
mitochondrion	HDA	24769239

GO Hierarchy

cellular component

cellular anatomical entity [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

fungal-type vacuole membrane

organelle outer membrane [inference]

mitochondrial outer membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

microbody [inference]

peroxisome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

endocytic patch [inference]

actin cortical patch

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
GTPase activity	IDA	8299420
GTPase activity	IBA
GTPase activity	IEA
GTP binding	IEA
microtubule binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

tubulin binding [inference]

microtubule binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Subunit A

Functional Category

C: Energy production and conversion
K: Transcription
L: Replication, recombination and repair

Displaying **all 2** entries
Gene Ontology
GTP binding
nucleotide binding

Displaying **all 2** entries
InterPro
Dynamin
P-loop containing nucleoside triphosphate hydrolase

Alliance of Genome Resources

Expression

Displaying **all 7** entries
Location	References
late endosome	PMID:23385815
mitochondrion	PMID:24769239
actin cortical patch	PMID:20841380
mitochondrial outer membrane	PMID:16407407
cytosol	PMID:26928762
fungal-type vacuole membrane	PMID:15550248
peroxisome	PMID:16520372

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0060558	lethal congenital contracture syndrome	Alliance of Genome Resources
DOID:0110197	Charcot-Marie-Tooth disease dominant intermediate B	Alliance of Genome Resources
DOID:0111223	centronuclear myopathy 1	Alliance of Genome Resources
DOID:0112202	developmental and epileptic encephalopathy	Alliance of Genome Resources
DOID:11252	microcytic anemia	Alliance of Genome Resources
DOID:2476	hereditary spastic paraplegia	Alliance of Genome Resources

Ortholog

Displaying **all 10** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	1759	ZFIN:ZDB-GENE-100920-3
Xenopus tropicalis	1785	Xenbase:XB-GENE-959257
Xenopus tropicalis	10059	Xenbase:XB-GENE-487279
Danio rerio	13429	ZFIN:ZDB-GENE-100920-3
Xenopus tropicalis	13430	Xenbase:XB-GENE-959257
Xenopus tropicalis	74006	Xenbase:XB-GENE-487279
Danio rerio	103967	ZFIN:ZDB-GENE-040724-76
Xenopus tropicalis	114114	Xenbase:XB-GENE-487279
Danio rerio	140694	ZFIN:ZDB-GENE-100920-3
Xenopus tropicalis	853870	Xenbase:XB-GENE-959257

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Last updated: December 8, 2025