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regulator of G protein signaling 8

Summary

Gene Symbol

RGS8

Organism

Homo sapiens (human)

External Links

NCBI Gene

85397

PubChem

85397

Alliance of Genome Resources

HGNC:16810

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell projection
GTPase activation
Nucleus
Phosphoprotein
Reference proteome
Signal transduction inhibitor

Proteins

Displaying 1 entry
UniProt	Protein Name
P57771

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
G protein-coupled receptor signaling pathway	TAS
G protein-coupled acetylcholine receptor signaling pathway	ISS
negative regulation of signal transduction	IEA
positive regulation of GTPase activity	IDA	18434541
regulation of dopamine receptor signaling pathway	ISS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of response to stimulus [inference]

negative regulation of signal transduction

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

G protein-coupled acetylcholine receptor signaling pathway

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway [inference]

G protein-coupled acetylcholine receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

regulation of hydrolase activity [inference]

regulation of GTPase activity [inference]

positive regulation of GTPase activity

positive regulation of hydrolase activity [inference]

positive regulation of GTPase activity

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
plasma membrane	TAS
cytoplasmic side of plasma membrane	ISS
dendrite	ISS
neuronal cell body membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

cell body membrane [inference]

neuronal cell body membrane

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
GTPase activity	TAS
GTPase activator activity	IDA	18434541
protein binding	IPI	25416956 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

GTPase activator activity

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Regulator of G-protein signaling

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
RGS domain superfamily
RGS domain
RGS, subdomain 1/3
RGS, subdomain 2

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	5996	WB:WBGene00004350
Rattus norvegicus	54297		RATNO06720
Mus musculus	67792		MOUSE27483
Xenopus tropicalis	85397	Xenbase:XB-GENE-990044
Danio rerio	436804		DANRE38086
Canis lupus familiaris	490311		CANLF17167
Macaca mulatta	720353		MACMU21254
Pan troglodytes	743247		PANTR23177
Bos taurus	781543		BOVIN08751
Monodelphis domestica	100018071		MONDO15796