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solute carrier family 5 member 7

Summary

Gene Symbol

Slc5a7

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

85426

PubChem

85426

Alliance of Genome Resources

RGD:69270

Annotation

Keyword

Cell membrane
Cell projection
Cytoplasmic vesicle
Endosome
Glycoprotein
Neurotransmitter biosynthesis
Phosphoprotein
Reference proteome
Sodium transport
Symport
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9JMD7	Hemicholinium-3-sensitive choline transporter Solute carrier family 5 member 7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
in utero embryonic development	ISO
in utero embryonic development	IEA
sodium ion transport	IEA
synaptic transmission, cholinergic	ISO
synaptic transmission, cholinergic	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

acetylcholine biosynthetic process

biosynthetic process [inference]

organic substance biosynthetic process [inference]

acetate ester biosynthetic process [inference]

acetylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

acetylcholine biosynthetic process

organic substance metabolic process [inference]

acetate ester metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine biosynthetic process

acetate ester biosynthetic process [inference]

acetylcholine biosynthetic process

organonitrogen compound metabolic process [inference]

acetylcholine metabolic process [inference]

acetylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

acetylcholine biosynthetic process

organic substance biosynthetic process [inference]

acetate ester biosynthetic process [inference]

acetylcholine biosynthetic process

organonitrogen compound biosynthetic process [inference]

acetylcholine biosynthetic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

transmembrane transport

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

transmembrane transport

organic substance transport [inference]

organic cation transport [inference]

choline transport

quaternary ammonium group transport [inference]

choline transport

nitrogen compound transport [inference]

quaternary ammonium group transport [inference]

choline transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
early endosome	IDA	15953352
plasma membrane	ISO
plasma membrane	IBA
synaptic vesicle	IDA	20394050
membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft

cell junction [inference]

synapse

neuromuscular junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
choline:sodium symporter activity	ISS
choline:sodium symporter activity	ISO
choline:sodium symporter activity	IBA
protein binding	IPI	17092608
choline transmembrane transporter activity	ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

organic cation transmembrane transporter activity [inference]

quaternary ammonium group transmembrane transporter activity [inference]

choline transmembrane transporter activity

choline:sodium symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

choline:sodium symporter activity

choline transmembrane transporter activity

choline:sodium symporter activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

choline binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

high affinity choline transporter 1

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
acetylcholine biosynthetic process
choline transport
choline
monoatomic ion transport
symporter activity

Displaying **all 2** entries
InterPro
Sodium/glucose symporter superfamily
Sodium/solute symporter

Alliance of Genome Resources

Expression

Displaying **all 8** entries
Location	References
plasma membrane raft	PMID:24127780
dendrite	PMID:11904763
clathrin-coated endocytic vesicle	PMID:15953352
synaptic vesicle	PMID:20394050
early endosome	PMID:15953352
apical plasma membrane	PMID:12628461
perikaryon	PMID:11904763
axon	PMID:11904763

Ortholog

Displaying entries **1 - 10** of **132** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	42245	Xenbase:XB-GENE-961535
Homo sapiens	60482	Xenbase:XB-GENE-961535	HUMAN64209
Mus musculus	63993	Xenbase:XB-GENE-961535	MOUSE20013
Xenopus tropicalis	85426	Xenbase:XB-GENE-961535
Xenopus tropicalis	178274	Xenbase:XB-GENE-961535
Pan troglodytes	470492		PANTR28396
Canis lupus familiaris	481311		CANLF01720
Bos taurus	512311		BOVIN02466
Macaca mulatta	714093		MACMU07615
Danio rerio	100005589		DANRE17756