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isocitrate dehydrogenase (NAD(+)) IDH2

Summary

Gene Symbol

IDH2

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

854303

KEGG Gene ID

sce:YOR136W

PubChem

854303

Alliance of Genome Resources

SGD:S000005662

Annotation

Keyword

3D-structure
Allosteric enzyme
Direct protein sequencing
Magnesium
Manganese
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
RNA-binding
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying 1 entry
UniProt	Protein Name
P28241	Isocitric dehydrogenase NAD(+)-specific ICDH

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
tricarboxylic acid cycle	TAS	9175438
tricarboxylic acid cycle	IBA
tricarboxylic acid cycle	IEA
isocitrate metabolic process	IDA	16884682
isocitrate metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

glutamate biosynthetic process

amide metabolic process [inference]

glutamate metabolic process [inference]

glutamate biosynthetic process

amide biosynthetic process [inference]

glutamate biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

glutamate biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

glutamate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

glutamate biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

glutamate biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

glutamate biosynthetic process

primary metabolic process [inference]

tricarboxylic acid cycle

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

glutamate biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

glutamate biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

glutamate biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

glutamate biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

organic substance biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

organonitrogen compound biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process [inference]

glutamate biosynthetic process

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid metabolic process [inference]

glutamate metabolic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

tricarboxylic acid metabolic process [inference]

isocitrate metabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

glutamate biosynthetic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

glutamine family amino acid biosynthetic process [inference]

glutamate biosynthetic process

dicarboxylic acid biosynthetic process [inference]

glutamate biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

glutamate biosynthetic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrion	IDA	11502169
mitochondrion	IBA
mitochondrion	IEA
mitochondrion	HDA	11914276 14576278 16823961 24769239
mitochondrial matrix	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

tricarboxylic acid cycle enzyme complex [inference]

isocitrate dehydrogenase complex (NAD+)

oxidoreductase complex [inference]

isocitrate dehydrogenase complex (NAD+)

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IEA
RNA binding	IEA
isocitrate dehydrogenase (NAD+) activity	IDA	16884682
isocitrate dehydrogenase (NAD+) activity	IEA
oxidoreductase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

isocitrate dehydrogenase [NAD(P)+] activity [inference]

isocitrate dehydrogenase (NAD+) activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

cation binding [inference]

metal ion binding

magnesium ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
isocitrate dehydrogenase (NAD+) activity
isocitrate metabolic process
magnesium ion binding
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
tricarboxylic acid cycle

Displaying **all 3** entries
InterPro
Isocitrate dehydrogenase NAD-dependent
Isocitrate/isopropylmalate dehydrogenase, conserved site
Isopropylmalate dehydrogenase-like domain

KEGG BRITE Database

Orthology

K00030

Name

isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]

References

10601238

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
mitochondrion	PMID:11502169 PMID:11914276 PMID:14576278 PMID:16823961 PMID:24769239
isocitrate dehydrogenase complex (NAD+)	PMID:16884682

Rhea

RHEA:23632

D-threo-isocitrate + NAD⁺

CO₂ + 2-oxoglutarate + NADH

Enzyme

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050709	early infantile epileptic encephalopathy	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	3419	Xenbase:XB-GENE-943186
Xenopus tropicalis	67834	Xenbase:XB-GENE-943186
Xenopus tropicalis	114096	Xenbase:XB-GENE-943186
Xenopus tropicalis	854303	Xenbase:XB-GENE-943186

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements