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selenoprotein I

Summary

Gene Symbol

SELENOI

Aliases

KIAA1724
SELI
SEPI

Organism

Homo sapiens (human)

External Links

NCBI Gene

85465

HGNC

29361

KEGG Gene ID

hsa:85465

PubChem

85465

Alliance of Genome Resources

HGNC:29361

Annotation

Keyword

Acetylation
Disease variant
Endoplasmic reticulum
Hereditary spastic paraplegia
Magnesium
Manganese
Metal-binding
Phospholipid biosynthesis
Reference proteome
Selenocysteine
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9C0D9	Selenoprotein I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
phosphatidylethanolamine biosynthetic process	IBA IDA IEA IMP	17132865 28052917 29500230

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine biosynthetic process

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylethanolamine biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA TAS
Golgi apparatus	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
ethanolaminephosphotransferase activity	IBA IDA IMP	17132865 28052917 29500230
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

phosphotransferase activity, for other substituted phosphate groups [inference]

CDP-alcohol phosphatidyltransferase activity [inference]

ethanolaminephosphotransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000138018

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00993

Name

ethanolaminephosphotransferase [EC:2.7.8.1]

References

17132865

Rhea

CDP-ethanolamine + 1-O-(1Z-alkenyl)-2-acyl-sn-glycerol

H⁺ + CMP + 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine

Enzyme

2.7.8.1

a 1,2-diacyl-sn-glycerol + CDP-ethanolamine

H⁺ + CMP + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine

Enzyme

2.7.8.1

PMID

Disease

Disease Ontology

Displaying entries **11 - 20** of 71 in total

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DO ID	Disease Name	Source
DOID:0110767	hereditary spastic paraplegia 14	DisGeNET
DOID:0110768	hereditary spastic paraplegia 15	DisGeNET
DOID:0110769	hereditary spastic paraplegia 16	DisGeNET
DOID:0110770	hereditary spastic paraplegia 17	DisGeNET
DOID:0110771	hereditary spastic paraplegia 18	DisGeNET
DOID:0110772	hereditary spastic paraplegia 19	DisGeNET
DOID:0110773	hereditary spastic paraplegia 2	DisGeNET
DOID:0110774	hereditary spastic paraplegia 23	DisGeNET
DOID:0110775	hereditary spastic paraplegia 24	DisGeNET
DOID:0110776	hereditary spastic paraplegia 25	DisGeNET

The Human Phenotype Ontology

Displaying entries **11 - 20** of 33 in total

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HPO ID	HPO Term
HP:0001270	Motor delay
HP:0001347	Hyperreflexia
HP:0002061	Lower limb spasticity
HP:0002191	Progressive spasticity
HP:0002194	Delayed gross motor development
HP:0002395	Lower limb hyperreflexia
HP:0002493	Upper motor neuron dysfunction
HP:0002540	Inability to walk
HP:0003487	Babinski sign
HP:0003623	Neonatal onset

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:506353	autosomal recessive complex spastic paraplegia due to kennedy pathway dysfunction
OMIM:618768	spastic paraplegia 81, autosomal recessive

PubChem Disease

MedGen Diseases

Spastic paraplegia 81, autosomal recessive

OMIM Phenotypes

SPASTIC PARAPLEGIA 81, AUTOSOMAL RECESSIVE; SPG81

KEGG Diseases

Hereditary spastic paraplegia

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012361
Gene Name: ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)

Ortholog

Displaying entries **51 - 60** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ursus maritimus	103671667		URSMA00854
Vombatus ursinus	114034729		VOMUR15476
Vicugna pacos	102540590		VICPA02989
Otolemur garnettii	100956796		OTOGA14032
Takifugu rubripes	101080212		TAKRU15398
Chinchilla lanigera	102011299		CHILA16762
Aotus nancymaae	105733208		AOTNA11974
Phascolarctos cinereus	110206507		PHACI17994
Ictidomys tridecemlineatus	101955181		ICTTR13537
Myotis lucifugus	102433803		MYOLU12248

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Last updated: August 19, 2024