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MIRAGE

protein disulfide isomerase EPS1

Summary

Gene Symbol

EPS1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

854812

PubChem

854812

Alliance of Genome Resources

SGD:S000001267

Annotation

Keyword

Chaperone
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Isomerase
Redox-active center
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P40557

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein folding	IBA
protein retention in ER lumen	IMP	10545109
ERAD pathway	IMP	12881414

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

protein folding

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

maintenance of protein localization in organelle [inference]

maintenance of protein localization in endoplasmic reticulum [inference]

protein retention in ER lumen

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

localization [inference]

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in cell [inference]

maintenance of protein localization in organelle [inference]

maintenance of protein localization in endoplasmic reticulum [inference]

protein retention in ER lumen

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

maintenance of protein localization in organelle [inference]

maintenance of protein localization in endoplasmic reticulum [inference]

protein retention in ER lumen

Displaying entries **1 - 5** of 8 in total

1

2

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GO Term	Evidence Code	PMID
cytoplasm	IEA
endoplasmic reticulum	IBA
endoplasmic reticulum	IEA
endoplasmic reticulum membrane	IDA	10545109
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle

endoplasmic reticulum

Displaying entries **1 - 5** of 7 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
protein disulfide isomerase activity	IMP	11157982
protein disulfide isomerase activity	IBA
protein disulfide isomerase activity	IEA
protein binding	IPI	16002399
isomerase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on a sulfur group of donors [inference]

disulfide oxidoreductase activity [inference]

protein-disulfide reductase activity [inference]

protein-disulfide reductase (glutathione) activity

oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [inference]

protein-disulfide reductase (glutathione) activity

isomerase activity

intramolecular oxidoreductase activity [inference]

intramolecular oxidoreductase activity, transposing S-S bonds [inference]

protein disulfide isomerase activity

catalytic activity, acting on a protein [inference]

protein disulfide isomerase activity

protein-disulfide reductase activity [inference]

protein-disulfide reductase (glutathione) activity

binding [inference]

protein binding

unfolded protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

disulfide isomerase

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
InterPro
Thioredoxin domain
Thioredoxin-like superfamily

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
endoplasmic reticulum membrane	PMID:10545109

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026