GlyCosmos Portal

Annotation

Keyword

DNA repair
Glycosidase
Lyase
Multifunctional enzyme
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P53397

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
base-excision repair	IEA
DNA repair	IEA IMP	11239005
error-free translesion synthesis	IGI	19264809
base-excision repair, AP site formation	IBA IDA IEA	8643552
telomere maintenance via telomerase	IMP	19942858

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

base-excision repair, AP site formation

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

RNA-templated DNA biosynthetic process [inference]

telomere maintenance via telomerase

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance [inference]

telomere maintenance via telomere lengthening [inference]

telomere maintenance via telomerase

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

postreplication repair [inference]

translesion synthesis [inference]

error-free translesion synthesis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion	IDA	11239005
nucleus	IBA IDA IEA	11239005

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
oxidized base lesion DNA N-glycosylase activity	IEA
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	IBA IEA
lyase activity	IEA
hydrolase activity, acting on glycosyl bonds	IEA
class I DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity [inference]

oxidized base lesion DNA N-glycosylase activity

oxidized purine nucleobase lesion DNA N-glycosylase activity

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

lyase activity

carbon-oxygen lyase activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA-(apurinic or apyrimidinic site) endonuclease activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA N-glycosylase activity [inference]

oxidized base lesion DNA N-glycosylase activity

oxidized purine nucleobase lesion DNA N-glycosylase activity

8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glycosylase

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
DNA repair
base-excision repair, AP site formation
base-excision repair
catalytic activity
damaged DNA binding

Displaying **all 4** entries
InterPro
8-oxoguanine DNA glycosylase, N-terminal
DNA glycosylase
Helix-hairpin-helix, base-excision DNA repair, C-terminal
HhH-GPD domain

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
nucleus	PMID:11239005
mitochondrion	PMID:11239005

Disease

Disease Ontology

Displaying entries **11 - 20** of 26 in total

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DO ID	Disease Name	Source
DOID:1824	status epilepticus	Alliance of Genome Resources
DOID:2237	hepatitis	Alliance of Genome Resources
DOID:224	transient cerebral ischemia	Alliance of Genome Resources
DOID:2394	ovarian cancer	Alliance of Genome Resources
DOID:2513	basal cell carcinoma	Alliance of Genome Resources
DOID:2671	transitional cell carcinoma	Alliance of Genome Resources
DOID:3314	angiomyolipoma	Alliance of Genome Resources
DOID:3393	coronary artery disease	Alliance of Genome Resources
DOID:3525	middle cerebral artery infarction	Alliance of Genome Resources
DOID:4450	renal cell carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 28** of 28 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Kluyveromyces marxianus DMKU3-1042	34716786	1003335_0:000ca8
Saccharomyces paradoxus	54632649	27291_0:000f52
Zygotorulaspora mrakii	59236847	42260_0:000d2d
Torulaspora globosa	59325549	48254_0:00079f
Kazachstania barnettii	64860120	61262_0:0000b9
Saccharomyces mikatae IFO 1815	80920298	226126_0:000f87
Saccharomyces kudriavzevii IFO 1802	80926108	226230_0:000fa8
Xenopus tropicalis	100380072		Xenbase:XB-GENE-995809

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements