GlyCosmos Portal

Annotation

Keyword

3D-structure
4Fe-4S
Acetylation
DNA replication
DNA-binding
DNA-directed DNA polymerase
Nucleus
Phosphoprotein
Reference proteome
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
P13382	DNA polymerase I subunit A DNA polymerase alpha:primase complex p180 subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
RNA-templated DNA biosynthetic process	IDA	17429354
lagging strand elongation	IBA
DNA synthesis involved in DNA repair	IMP	2651896
DNA replication	IEA IMP	2651896
mitotic DNA replication initiation	IBA IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication [inference]

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

double-strand break repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

DNA biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication [inference]

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

double-strand break repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

DNA biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication [inference]

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

double-strand break repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

DNA biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication [inference]

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

double-strand break repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

DNA biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication [inference]

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

double-strand break repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

DNA biosynthetic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication [inference]

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

double-strand break repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

DNA biosynthetic process [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication [inference]

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

double-strand break repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

DNA biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

cellular process [inference]

cell cycle process [inference]

cell cycle DNA replication [inference]

nuclear DNA replication [inference]

premeiotic DNA replication

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

meiotic cell cycle process [inference]

premeiotic DNA replication

mitotic cell cycle process [inference]

mitotic DNA replication initiation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication [inference]

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

double-strand break repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

DNA biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication [inference]

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

double-strand break repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

DNA biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication [inference]

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

double-strand break repair

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

DNA biosynthetic process [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

reproductive process [inference]

meiotic cell cycle process [inference]

premeiotic DNA replication

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

Displaying **all 5** entries
GO Term	Evidence Code	PMID
alpha DNA polymerase:primase complex	IBA IDA	22593576 3888995
intracellular membrane-bounded organelle	IEA
mitochondrion	HDA	16823961
nucleus	IEA
replication fork	IDA	15773893

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

DNA polymerase complex [inference]

alpha DNA polymerase:primase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

alpha DNA polymerase:primase complex

DNA polymerase complex [inference]

alpha DNA polymerase:primase complex

cellular anatomical entity [inference]

replication fork

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
zinc ion binding	RCA	30358795
DNA binding	IEA
chromatin binding	IBA
metal ion binding	IEA
single-stranded DNA binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

chromatin binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

single-stranded DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

nucleoside phosphate binding [inference]

nucleotide binding

molecular carrier activity [inference]

protein carrier chaperone [inference]

histone chaperone activity [inference]

H3-H4 histone complex chaperone activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA polymerase I

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
DNA biosynthetic process
DNA replication origin binding
chromatin binding
lagging strand elongation
leading strand elongation
metal ion binding
mitotic DNA replication initiation
nucleotide binding
nucleotidyltransferase activity
transferase activity

Displaying entries **1 - 10** of 13 in total

1

2

Next ›

Last »
InterPro
DNA polymerase alpha catalytic subunit, N-terminal domain
DNA polymerase alpha catalytic subunit, catalytic domain
DNA polymerase alpha, zinc finger domain superfamily
DNA polymerase family B, thumb domain
DNA polymerase, palm domain superfamily
DNA-directed DNA polymerase, family B, conserved site
DNA-directed DNA polymerase, family B, exonuclease domain
DNA-directed DNA polymerase, family B, multifunctional domain
DNA-directed DNA polymerase, family B
DNA/RNA polymerase superfamily

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
mitochondrion	PMID:16823961
replication fork	PMID:15773893
alpha DNA polymerase	PMID:22593576 PMID:3888995

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111834	X-linked reticulate pigmentary disorder	Alliance of Genome Resources
DOID:0111840	Van Esch-O'Driscoll syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 28 in total

1

2

3

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	5422		HGNC:9173
Mus musculus	18968		MGI:99660
Drosophila melanogaster	42553		FB:FBgn0259113
Rattus norvegicus	85241		RGD:621816
Caenorhabditis elegans	176544		WB:WBGene00012936
Danio rerio	317740		ZFIN:ZDB-GENE-030114-9
Kluyveromyces lactis	2892012	28985_0:00059f
Eremothecium gossypii ATCC 10895	4621453	284811_0:000979
Lachancea thermotolerans CBS 6340	8295342	559295_0:0006c8
Eremothecium cymbalariae DBVPG#7215	11468483	931890_0:000ba7

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements