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ATP-binding cassette long-chain fatty acid transporter PXA1

Summary

Gene Symbol

PXA1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

855956

PubChem

855956

Alliance of Genome Resources

SGD:S000006068

Annotation

Keyword

ATP-binding
Glycoprotein
Peroxisome
Reference proteome
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
P41909	Peroxisomal ABC transporter 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

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GO Term	Evidence Code	PMID
ATP transport	IDA	35127709
long-chain fatty acid catabolic process
very long-chain fatty acid catabolic process	IBA
peroxisome organization	IBA
fatty-acyl-CoA transport

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid catabolic process

long-chain fatty acid metabolic process [inference]

long-chain fatty acid catabolic process

fatty acid catabolic process [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid catabolic process

long-chain fatty acid metabolic process [inference]

long-chain fatty acid catabolic process

fatty acid catabolic process [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid catabolic process

long-chain fatty acid metabolic process [inference]

long-chain fatty acid catabolic process

fatty acid catabolic process [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid catabolic process

long-chain fatty acid metabolic process [inference]

long-chain fatty acid catabolic process

fatty acid catabolic process [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid catabolic process

long-chain fatty acid metabolic process [inference]

long-chain fatty acid catabolic process

fatty acid catabolic process [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid catabolic process

long-chain fatty acid metabolic process [inference]

long-chain fatty acid catabolic process

fatty acid catabolic process [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid catabolic process

long-chain fatty acid metabolic process [inference]

long-chain fatty acid catabolic process

fatty acid catabolic process [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

monocarboxylic acid catabolic process [inference]

fatty acid catabolic process [inference]

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

very long-chain fatty acid metabolic process [inference]

very long-chain fatty acid catabolic process

long-chain fatty acid metabolic process [inference]

long-chain fatty acid catabolic process

fatty acid catabolic process [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

lipid modification [inference]

lipid oxidation [inference]

fatty acid oxidation [inference]

fatty acid beta-oxidation

cellular lipid catabolic process [inference]

fatty acid catabolic process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

long-chain fatty acid import into peroxisome

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

long-chain fatty acid import into peroxisome

transmembrane transport [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import into peroxisome

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

peroxisome organization

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

long-chain fatty acid import into peroxisome

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

long-chain fatty acid import into peroxisome

transmembrane transport [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import into peroxisome

organic substance transport [inference]

lipid transport [inference]

fatty acid transport

long-chain fatty acid transport [inference]

long-chain fatty acid import into peroxisome

fatty acid transmembrane transport [inference]

long-chain fatty acid import into peroxisome

intracellular lipid transport [inference]

long-chain fatty acid import into peroxisome

organic anion transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport

long-chain fatty acid transport [inference]

long-chain fatty acid import into peroxisome

fatty acid transmembrane transport [inference]

long-chain fatty acid import into peroxisome

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import into peroxisome

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

adenine nucleotide transport [inference]

organic acid transport [inference]

carboxylic acid transport [inference]

monocarboxylic acid transport [inference]

fatty acid transport

long-chain fatty acid transport [inference]

long-chain fatty acid import into peroxisome

fatty acid transmembrane transport [inference]

long-chain fatty acid import into peroxisome

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import into peroxisome

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

fatty acid transmembrane transport [inference]

long-chain fatty acid import into peroxisome

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

adenine nucleotide transport [inference]

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

thioester transport [inference]

fatty-acyl-CoA transport

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

purine ribonucleotide transport [inference]

adenine nucleotide transport [inference]

amide transport [inference]

fatty-acyl-CoA transport

sulfur compound transport [inference]

thioester transport [inference]

fatty-acyl-CoA transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

long-chain fatty acid import into peroxisome

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

long-chain fatty acid import into peroxisome

cellular localization [inference]

intracellular transport [inference]

intracellular lipid transport [inference]

long-chain fatty acid import into peroxisome

peroxisomal transport [inference]

peroxisomal membrane transport [inference]

long-chain fatty acid import into peroxisome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	IEA
peroxisome	IEA
ATP-binding cassette (ABC) transporter complex
peroxisomal membrane	IBA IDA IEA	35127709 8670886

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

ATP-binding cassette (ABC) transporter complex

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

transporter complex [inference]

transmembrane transporter complex [inference]

ATPase dependent transmembrane transport complex [inference]

ATP-binding cassette (ABC) transporter complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

microbody membrane [inference]

peroxisomal membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

microbody membrane [inference]

peroxisomal membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ABC-type transporter activity	IEA
ATP hydrolysis activity	IEA
ATPase-coupled transmembrane transporter activity	IBA IDA IMP	35127709 8670886
ATP binding	IBA IEA
long-chain fatty acid transporter activity	IBA IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

lipid transporter activity [inference]

long-chain fatty acid transporter activity

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity

ABC-type transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ATP-binding cassette sub-family D member

Functional Category

J: Translation, ribosomal structure and biogenesis
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ABC-type transporter activity
ATP binding
fatty acid beta-oxidation
long-chain fatty acid import into peroxisome
nucleotide binding
peroxisome organization
very long-chain fatty acid catabolic process

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
peroxisomal membrane	PMID:35127709 PMID:8670886

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0111066	congenital bile acid synthesis defect 5	Alliance of Genome Resources
DOID:10588	adrenoleukodystrophy	Alliance of Genome Resources
DOID:905	Zellweger syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 39 in total

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Species	Gene ID	Alliance of Genome Resources
Homo sapiens	215	HGNC:61
Homo sapiens	5825	HGNC:67
Mus musculus	11666	MGI:1349215
Mus musculus	19299	MGI:1349216
Rattus norvegicus	25270	RGD:2007
Mus musculus	26874	MGI:1349467
Drosophila melanogaster	32992	FB:FBgn0031069
Drosophila melanogaster	43772	FB:FBgn0039890
Rattus norvegicus	84356	RGD:69244
Caenorhabditis elegans	174126	WB:WBGene00004058

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International Collaboration

Acknowledgements