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Annotation

Keyword

3D-structure
Cell cycle
DNA replication
DNA-binding
Helicase
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P30665	Cell division control protein 54

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
double-strand break repair via break-induced replication	IBA IEA IMP	20516198
DNA replication	IEA
mitotic DNA replication initiation	IBA
DNA strand elongation involved in DNA replication	IBA IMP	10834843
nuclear DNA replication	IMP	2044962

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular process [inference]

cell cycle process [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

pre-replicative complex assembly involved in cell cycle DNA replication [inference]

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

meiotic cell cycle process [inference]

premeiotic DNA replication

mitotic cell cycle process [inference]

mitotic DNA replication initiation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA geometric change [inference]

DNA duplex unwinding

DNA unwinding involved in DNA replication

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

pre-replicative complex assembly [inference]

pre-replicative complex assembly involved in cell cycle DNA replication [inference]

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

pre-replicative complex assembly [inference]

pre-replicative complex assembly involved in cell cycle DNA replication [inference]

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

protein-DNA complex organization [inference]

protein-DNA complex assembly [inference]

pre-replicative complex assembly [inference]

pre-replicative complex assembly involved in cell cycle DNA replication [inference]

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

reproductive process [inference]

meiotic cell cycle process [inference]

premeiotic DNA replication

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
replication fork protection complex	IDA IEA	16531994
MCM core complex	IDA	13679365
nuclear pre-replicative complex	IDA IEA	16824194 9335335
MCM complex	IBA IDA IEA	12480933
nucleoplasm

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

DNA replication preinitiation complex

CMG complex

pre-replicative complex [inference]

nuclear pre-replicative complex

nuclear protein-containing complex [inference]

nuclear pre-replicative complex

DNA replication preinitiation complex

CMG complex

replication fork protection complex

cellular anatomical entity [inference]

nucleoplasm

replication fork [inference]

nuclear replication fork

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
zinc ion binding	RCA	30358795
DNA binding	IEA
hydrolase activity	IEA
helicase activity	IEA
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity

DNA helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

single-stranded DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity

DNA helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA replication licensing factor

Functional Category

H: Coenzyme transport and metabolism
K: Transcription
L: Replication, recombination and repair
V: Defense mechanisms

Displaying **all 8** entries
Gene Ontology
ATP binding
DNA duplex unwinding
DNA strand elongation involved in DNA replication
DNA unwinding involved in DNA replication
double-strand break repair via break-induced replication
hydrolase activity
mitotic DNA replication initiation
nucleotide binding

Displaying **all 9** entries
InterPro
MCM OB domain
MCM domain
MCM, AAA-lid domain
MCM, N-terminal domain
Mini-chromosome maintenance complex protein 4
Mini-chromosome maintenance protein
Mini-chromosome maintenance, conserved site
Nucleic acid-binding, OB-fold
P-loop containing nucleoside triphosphate hydrolase

Alliance of Genome Resources

Expression

Displaying **all 9** entries
Location	References
nuclear replication fork	PMID:16103218
cytoplasm	PMID:10559985 PMID:10704410
MCM core complex	PMID:13679365
nucleus	PMID:10559985 PMID:10704410
replication fork protection complex	PMID:16531994
DNA replication preinitiation complex	PMID:9554851
CMG complex	PMID:26524492
MCM complex	PMID:12480933
nuclear pre-replicative complex	PMID:16824194 PMID:9335335

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111967	immunodeficiency 54	Alliance of Genome Resources
DOID:1380	endometrial cancer	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 30 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	4173		HGNC:6947
Mus musculus	17217		MGI:103199
Rattus norvegicus	29728		RGD:3060
Drosophila melanogaster	35679		FB:FBgn0015929
Caenorhabditis elegans	171793		WB:WBGene00003156
Danio rerio	337598		ZFIN:ZDB-GENE-030131-9544
Xenopus tropicalis	448137		Xenbase:XB-GENE-1011481
Kluyveromyces lactis	2891932	28985_0:000798
Eremothecium gossypii ATCC 10895	4620219	284811_0:000840
Vanderwaltozyma polyspora DSM 70294	5542522	436907_0:0000eb

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements