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Annotation

Keyword

3D-structure
Cell cycle
DNA replication
DNA-binding
Helicase
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P30665	Cell division control protein 54

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
double-strand break repair via break-induced replication	IMP	20516198
double-strand break repair via break-induced replication	IBA
double-strand break repair via break-induced replication	IEA
DNA replication	IDA	13679365 15723534
DNA replication	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular process [inference]

cell cycle process [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

pre-replicative complex assembly involved in cell cycle DNA replication [inference]

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

meiotic cell cycle process [inference]

premeiotic DNA replication

mitotic cell cycle process [inference]

mitotic DNA replication initiation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication [inference]

cell cycle DNA replication [inference]

nuclear DNA replication

premeiotic DNA replication

DNA replication initiation

cell cycle DNA replication initiation [inference]

nuclear cell cycle DNA replication initiation [inference]

mitotic DNA replication initiation

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

DNA conformation change [inference]

DNA geometric change [inference]

DNA duplex unwinding [inference]

DNA unwinding involved in DNA replication

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

pre-replicative complex assembly [inference]

pre-replicative complex assembly involved in cell cycle DNA replication [inference]

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

pre-replicative complex assembly [inference]

pre-replicative complex assembly involved in cell cycle DNA replication [inference]

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

protein-DNA complex organization [inference]

chromatin organization [inference]

protein-DNA complex assembly [inference]

pre-replicative complex assembly [inference]

pre-replicative complex assembly involved in cell cycle DNA replication [inference]

pre-replicative complex assembly involved in nuclear cell cycle DNA replication

reproductive process [inference]

meiotic cell cycle process [inference]

premeiotic DNA replication

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

double-strand break repair via break-induced replication

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	10559985 10704410
nucleus	IBA
nucleus	IEA
nucleoplasm
nuclear pre-replicative complex	IDA	16824194 9335335

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

DNA replication preinitiation complex

CMG complex

pre-replicative complex [inference]

nuclear pre-replicative complex

nuclear protein-containing complex [inference]

nuclear pre-replicative complex

DNA replication preinitiation complex

CMG complex

replication fork protection complex

cellular anatomical entity [inference]

nucleoplasm

replication fork [inference]

nuclear replication fork

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
DNA binding	IEA
DNA helicase activity	IDA	15723534
DNA helicase activity	IEA
DNA replication origin binding	IDA	11756674 16824194
DNA replication origin binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a protein [inference]

ATP-dependent histone chaperone activity [inference]

catalytic activity, acting on a nucleic acid [inference]

helicase activity

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

DNA clamp loader activity

DNA translocase activity [inference]

chromatin extrusion motor activity

ATP-dependent chromatin remodeler activity [inference]

ATP-dependent histone chaperone activity [inference]

cohesin loader activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

single-stranded DNA binding

sequence-specific DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

DNA replication origin binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

molecular carrier activity [inference]

protein carrier chaperone [inference]

histone chaperone activity [inference]

H3-H4 histone complex chaperone activity [inference]

ATP-dependent H3-H4 histone complex chaperone activity

ATP-dependent histone chaperone activity [inference]

ATP-dependent activity [inference]

helicase activity

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

four-way junction helicase activity

single-stranded DNA helicase activity

single-stranded 3'-5' DNA helicase activity

double-stranded DNA helicase activity

3'-5' DNA helicase activity

single-stranded 3'-5' DNA helicase activity

forked DNA-dependent helicase activity

DNA clamp loader activity

DNA translocase activity [inference]

chromatin extrusion motor activity

ATP-dependent chromatin remodeler activity [inference]

ATP-dependent histone chaperone activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA replication licensing factor

Functional Category

H: Coenzyme transport and metabolism
K: Transcription
L: Replication, recombination and repair

Displaying **all 8** entries
Gene Ontology
ATP binding
DNA duplex unwinding
DNA strand elongation involved in DNA replication
DNA unwinding involved in DNA replication
double-strand break repair via break-induced replication
hydrolase activity
mitotic DNA replication initiation
nucleotide binding

Displaying **all 9** entries
InterPro
MCM OB domain
MCM domain
MCM, AAA-lid domain
MCM, N-terminal domain
Mini-chromosome maintenance complex protein 4
Mini-chromosome maintenance protein
Mini-chromosome maintenance, conserved site
Nucleic acid-binding, OB-fold
P-loop containing nucleoside triphosphate hydrolase

Alliance of Genome Resources

Expression

Displaying **all 9** entries
Location	References
replication fork protection complex	PMID:16531994
cytoplasm	PMID:10559985 PMID:10704410
CMG complex	PMID:26524492
nucleus	PMID:10559985 PMID:10704410
nuclear pre-replicative complex	PMID:16824194 PMID:9335335
MCM core complex	PMID:13679365
nuclear replication fork	PMID:16103218
MCM complex	PMID:12480933
DNA replication preinitiation complex	PMID:9554851

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1380	endometrial cancer	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	4173	Xenbase:XB-GENE-1011481
Xenopus tropicalis	17217	Xenbase:XB-GENE-1011481
Xenopus tropicalis	856130	Xenbase:XB-GENE-1011481

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

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OrthoDB (Group)

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Acknowledgements