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Guidelines

MIRAGE

THO complex subunit 5

Summary

Gene Symbol

THOC5

Organism

Homo sapiens (human)

External Links

NCBI Gene

8563

PubChem

8563

Alliance of Genome Resources

HGNC:19074

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Differentiation
Isopeptide bond
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Ubl conjugation
mRNA splicing
mRNA transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13769	Functional spliceosome-associated protein 79 NF2/meningioma region protein pK1.3 Placental protein 39.2 hTREX90

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mRNA processing	IEA
mRNA export from nucleus	IDA	17190602
mRNA export from nucleus	IMP	22144908
mRNA export from nucleus	IBA
RNA splicing	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA metabolic process [inference]

mRNA processing

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

mononuclear cell differentiation [inference]

monocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis [inference]

primitive hemopoiesis

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis [inference]

primitive hemopoiesis

animal organ development [inference]

embryonic organ development [inference]

embryonic hemopoiesis [inference]

primitive hemopoiesis

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

mononuclear cell differentiation [inference]

monocyte differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

monocyte differentiation

cell development [inference]

hemopoiesis [inference]

embryonic hemopoiesis [inference]

primitive hemopoiesis

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

organic substance transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

establishment of RNA localization [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
transcription export complex	IDA	15833825 15998806
THO complex	IDA	15998806
THO complex part of transcription export complex	IDA	15998806
THO complex part of transcription export complex	IBA
chromosome, telomeric region	IDA	24270157

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

transcription export complex

THO complex part of transcription export complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

chromosomal region [inference]

chromosome, telomeric region

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mRNA binding	IBA
protein binding	IPI	19059247 19165146 22365833 23299939 26382858 26496610 28514442 33961781

GO Hierarchy

molecular function

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

mRNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

THO complex subunit

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
mRNA export from nucleus
positive regulation of DNA-templated transcription, elongation

Displaying 1 entry
InterPro
THO complex, subunit 5

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3459	breast carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	8563	Xenbase:XB-GENE-1015168
Mus musculus	107829		MOUSE06533
Danio rerio	325064		DANRE27283
Rattus norvegicus	360972		RATNO08753
Pan troglodytes	458742		PANTR26287
Canis lupus familiaris	477534		CANLF10460
Bos taurus	533001		BOVIN09795
Macaca mulatta	714842		MACMU01044
Monodelphis domestica	100018184		MONDO19591
Equus caballus	100059017		HORSE41335

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Last updated: December 8, 2025