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sphingosine N-acyltransferase LAG1

Summary

Gene Symbol

LAG1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

856386

PubChem

856386

Alliance of Genome Resources

SGD:S000000995

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Lipid biosynthesis
Phosphoprotein
Reference proteome
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P38703	Longevity assurance factor 1 Longevity assurance gene 1 protein Longevity assurance protein 1 Very-long-chain ceramide synthase LAG1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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2

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GO Term	Evidence Code	PMID
lipid metabolic process	IEA
sphingolipid metabolic process	IEA
ceramide biosynthetic process	IDA	15692566
ceramide biosynthetic process	IMP	11694577
ceramide biosynthetic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

amide metabolic process [inference]

ceramide metabolic process [inference]

ceramide biosynthetic process

amide biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

primary metabolic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process [inference]

ceramide biosynthetic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA
endoplasmic reticulum	HDA	11914276 14562095 22842922 26928762
endoplasmic reticulum membrane	IEA
membrane	IEA
acyl-CoA ceramide synthase complex	IDA	15692566

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

acyl-CoA ceramide synthase complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
transferase activity	IEA
sphingosine N-acyltransferase activity	IDA	15692566
sphingosine N-acyltransferase activity	IMP	11387200 11694577
sphingosine N-acyltransferase activity	IBA
sphingosine N-acyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

N-acyltransferase activity [inference]

sphingosine N-acyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Translocating chain-associated membrane protein

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ceramide biosynthetic process
sphingosine N-acyltransferase activity

Displaying 1 entry
InterPro
TRAM/LAG1/CLN8 homology domain

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
endoplasmic reticulum	PMID:11914276 PMID:14562095 PMID:22842922 PMID:26928762
acyl-CoA ceramide synthase complex	PMID:15692566

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources
DOID:9452	steatotic liver disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 12 in total

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Species	Gene ID	Alliance of Genome Resources
Xenopus tropicalis	29956	Xenbase:XB-GENE-852703
Danio rerio	67260	ZFIN:ZDB-GENE-110719-2
Xenopus tropicalis	71949	Xenbase:XB-GENE-852715
Xenopus tropicalis	76893	Xenbase:XB-GENE-852703
Danio rerio	79603	ZFIN:ZDB-GENE-110719-2
Xenopus tropicalis	91012	Xenbase:XB-GENE-852715
Xenopus tropicalis	180743	Xenbase:XB-GENE-957267
Xenopus tropicalis	204219	Xenbase:XB-GENE-957267
Xenopus tropicalis	241447	Xenbase:XB-GENE-854124
Xenopus tropicalis	253782	Xenbase:XB-GENE-854124

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Acknowledgements