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proteasome regulatory particle base subunit RPN1

Summary

Gene Symbol

RPN1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

856422

KEGG Gene ID

sce:YHR027C

PubChem

856422

Alliance of Genome Resources

SGD:S000001069

Annotation

Keyword

3D-structure
Direct protein sequencing
Phosphoprotein
Proteasome
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
P38764	HMG-CoA reductase degradation protein 2 Proteasome non-ATPase subunit 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
regulation of protein catabolic process	IEA
ubiquitin-dependent protein catabolic process		8982460 9697412

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of protein catabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	HDA	11914276

GO Hierarchy

cellular component

protein-containing complex [inference]

proteasome regulatory particle, base subcomplex

intracellular protein-containing complex [inference]

proteasome complex

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

proteasome storage granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

proteasome storage granule

Displaying **all 3** entries
GO Term	Evidence Code	PMID
enzyme regulator activity	IEA
protein-macromolecule adaptor activity	IPI	12198498
endopeptidase activity		8982460 9697412

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

26S proteasome regulatory non-ATPase subunit

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
proteasome-mediated ubiquitin-dependent protein catabolic process

Displaying **all 6** entries
InterPro
26S proteasome non-ATPase regulatory subunit RPN1, C-terminal
26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit
Armadillo-like helical
Armadillo-type fold
Proteasome/cyclosome repeat
RPN1, N-terminal

KEGG BRITE Database

Orthology

K03028

Name

26S proteasome regulatory subunit N1

References

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
proteasome storage granule	PMID:18504300
cytoplasm	PMID:11914276
endoplasmic reticulum	PMID:11914276
nucleus	PMID:15210724 PMID:26928762
proteasome regulatory particle, base subcomplex	PMID:9741626

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1289	neurodegenerative disease	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 29** of 29 in total

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Species	Gene ID	OrthoDB
Kazachstania naganishii CBS 8797	34526646	1071383_0:000bd1
Lachancea lanzarotensis	34685493	1245769_0:00087e
Kluyveromyces marxianus DMKU3-1042	34714568	1003335_0:0004a6
Saccharomyces paradoxus	54631005	27291_0:0009a9
Zygotorulaspora mrakii	59234165	42260_0:000077
Torulaspora globosa	59326651	48254_0:000ccc
Kazachstania barnettii	64857941	61262_0:000bdd
Saccharomyces mikatae IFO 1815	80918617	226126_0:000921
Saccharomyces kudriavzevii IFO 1802	80924427	226230_0:000936