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MAP kinase activating death domain

Summary

Gene Symbol

MADD

Organism

Homo sapiens (human)

External Links

NCBI Gene

8567

PubChem

8567

Alliance of Genome Resources

HGNC:6766

Annotation

Keyword

Alternative splicing
Apoptosis
Cell membrane
Cell projection
Cytoplasm
Guanine-nucleotide releasing factor
Intellectual disability
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0A0MRB5
Q8WXG6	Differentially expressed in normal and neoplastic cells Insulinoma glucagonoma clone 20 Rab3 GDP/GTP exchange factor Rab3 GDP/GTP exchange protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
execution phase of apoptosis	IMP	14735464
regulation of apoptotic process	IBA IMP	11577081
regulation of cell cycle	IMP	14735464

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

execution phase of apoptosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rab protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rab protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rab protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of programmed cell death [inference]

regulation of apoptotic process

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cell cycle

Displaying **all 5** entries
GO Term	Evidence Code	PMID
membrane	IDA	8988362
plasma membrane	IDA
axon	IEA
cytosol	IBA IDA TAS
cytoplasm	TAS	8988362

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16273344 21044950 9115275
death receptor binding	TAS	9115275
guanyl-nucleotide exchange factor activity	IBA IDA IMP TAS	20937701 9115275
protein kinase activator activity	TAS	9115275

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

tumor necrosis factor receptor superfamily binding [inference]

death receptor binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

MAP kinase-activating death domain protein

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
regulation of Rab protein signal transduction
regulation of apoptotic process

Displaying **all 6** entries
InterPro
DENN domain, C-terminal lobe
MAP kinase-activating death domain protein
Tripartite DENN domain
cDENN domain
dDENN domain
uDENN domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:224	transient cerebral ischemia	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **61 - 70** of 91 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Salmo salar	106587089		SALSA94439
Equus asinus asinus	106844010		EQUAS20961
Cyprinodon variegatus	107095310		CYPVA02075
Sinocyclocheilus grahami	107553062		SINGR42844
Sinocyclocheilus grahami	107563478		SINGR55819
Pygocentrus nattereri	108430834		PYGNA13770
Rhinopithecus bieti	108521964		RHIBE25780
Xenopus laevis	108713787	Xenbase:XB-GENE-17338004
Xenopus laevis	108715229	Xenbase:XB-GENE-6486758
Crocodylus porosus	109321154		CROPO08429

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements