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mRNA-binding ubiquitin-specific protease UBP3

Summary

Gene Symbol

UBP3

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

856895

PubChem

856895

Alliance of Genome Resources

SGD:S000000953

Annotation

Keyword

3D-structure
Reference proteome
Thiol protease
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q01477	Deubiquitinating enzyme 3 Ubiquitin thioesterase 3 Ubiquitin-specific-processing protease 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
regulation of protein stability	IBA
proteolysis	IEA
protein retention in Golgi apparatus	IGI IMP	32673164
protein deubiquitination	IDA IEA IMP	18498751 23476013 23645675
regulation of response to osmotic stress	IMP IPI	21743437

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

catabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy [inference]

ribophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy [inference]

ribophagy

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy [inference]

macroautophagy [inference]

ribophagy

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

protein retention in Golgi apparatus

process utilizing autophagic mechanism [inference]

autophagy [inference]

macroautophagy [inference]

ribophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

stress granule assembly

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

stress granule assembly

localization [inference]

maintenance of location [inference]

maintenance of protein location [inference]

maintenance of protein location in cell [inference]

protein retention in Golgi apparatus

maintenance of location in cell [inference]

maintenance of protein location in cell [inference]

protein retention in Golgi apparatus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

regulation of mitophagy [inference]

negative regulation of mitophagy

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

regulation of mitophagy [inference]

negative regulation of mitophagy

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

regulation of ER to Golgi vesicle-mediated transport

regulation of vesicle-mediated transport [inference]

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of ER to Golgi vesicle-mediated transport

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of response to stimulus [inference]

regulation of response to stress [inference]

regulation of response to osmotic stress

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of macroautophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

regulation of mitophagy [inference]

negative regulation of mitophagy

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of autophagy [inference]

negative regulation of macroautophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of mitochondrion organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of autophagy of mitochondrion [inference]

regulation of mitophagy [inference]

negative regulation of mitophagy

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of mitochondrion organization [inference]

negative regulation of autophagy of mitochondrion [inference]

negative regulation of mitophagy

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of ER to Golgi vesicle-mediated transport

regulation of vesicle-mediated transport [inference]

regulation of biological quality [inference]

regulation of protein stability

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrion
Ubp3-Bre5 deubiquitination complex	IPI	12778054
nucleus	IBA
cytosol	HDA IBA	26928762
cytoplasm	IDA	23222640

GO Hierarchy

cellular component

protein-containing complex [inference]

Ubp3-Bre5 deubiquitination complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cysteine-type deubiquitinase activity	IBA IDA IEA IMP	1429680 23476013
mRNA binding	HDA IDA	20844764 23222640
cysteine-type peptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

mRNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

UBIQUITIN CARBOXYL-TERMINAL HYDROLASE

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
hydrolase activity
proteolysis
regulation of autophagy

Displaying **all 4** entries
InterPro
Papain-like cysteine peptidase superfamily
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Ubiquitin specific protease domain
Ubiquitin specific protease, conserved site

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
Ubp3-Bre5 deubiquitination complex	PMID:12778054
cytoplasm	PMID:23222640
cytosol	PMID:26928762

Ortholog

Displaying entries **1 - 10** of 29 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	9100		HGNC:12608
Mus musculus	22224		MGI:894652
Drosophila melanogaster	38103		FB:FBgn0052479
Rattus norvegicus	307905		RGD:1561965
Xenopus tropicalis	448441		Xenbase:XB-GENE-966184
Danio rerio	564632		ZFIN:ZDB-GENE-030219-132
Kluyveromyces lactis	2894763	28985_0:000f1d
Eremothecium gossypii ATCC 10895	4623107	284811_0:0010f7
Vanderwaltozyma polyspora DSM 70294	5546981	436907_0:001100
Zygosaccharomyces rouxii	8202582	4956_0:00042f

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements