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aldo-keto reductase family 7 member A2

Summary

Gene Symbol

AKR7A2

Organism

Homo sapiens (human)

External Links

NCBI Gene

8574

PubChem

8574

Alliance of Genome Resources

HGNC:389

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Golgi apparatus
Lipid metabolism
Mitochondrion
NADP
Oxidoreductase
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4DZX4
V9HWA2
O43488	AFB1 aldehyde reductase 1 Aldoketoreductase 7 Succinic semialdehyde reductase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cellular aldehyde metabolic process	TAS	9576847
daunorubicin metabolic process	IMP	20837989
doxorubicin metabolic process	IMP	20837989
carbohydrate metabolic process	TAS	9576847
lipid metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

secondary metabolic process [inference]

polyketide metabolic process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process

cellular aromatic compound metabolic process [inference]

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

primary metabolic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

doxorubicin metabolic process

tertiary alcohol metabolic process [inference]

doxorubicin metabolic process

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

organic substance metabolic process [inference]

polyketide metabolic process [inference]

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

glycoside metabolic process [inference]

aminoglycoside antibiotic metabolic process [inference]

daunorubicin metabolic process

doxorubicin metabolic process

organic cyclic compound metabolic process [inference]

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

doxorubicin metabolic process

tertiary alcohol metabolic process [inference]

doxorubicin metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process

cellular aromatic compound metabolic process [inference]

cellular ketone metabolic process [inference]

quinone metabolic process [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IDA
mitochondrion	HTP	34800366
cytosol	IDA TAS
cytoplasm	IBA
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16189514 28514442 28536627 31515488 32296183 32814053 33961781
phenanthrene-9,10-epoxide hydrolase activity	IDA	20837989
electron transfer activity	TAS	9576847
alditol:NADP+ 1-oxidoreductase activity	TAS	9576847
aldo-keto reductase (NADP) activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

aldo-keto reductase (NADP) activity

alcohol dehydrogenase (NADP+) activity [inference]

alditol:NADP+ 1-oxidoreductase activity

hydrolase activity [inference]

hydrolase activity, acting on ether bonds [inference]

ether hydrolase activity [inference]

epoxide hydrolase activity [inference]

phenanthrene-epoxide hydrolase activity [inference]

phenanthrene-9,10-epoxide hydrolase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
K: Transcription

Displaying 1 entry
Gene Ontology
oxidoreductase activity

Displaying **all 2** entries
InterPro
NADP-dependent oxidoreductase domain superfamily
NADP-dependent oxidoreductase domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:3498	pancreatic ductal adenocarcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	110198		MGI:107796	MOUSE41620
Rattus norvegicus	171445		RGD:620311	RATNO33246
Xenopus tropicalis	447982		Xenbase:XB-GENE-996153
Xenopus laevis	734840		Xenbase:XB-GENE-996159
Pan troglodytes	748767	9598_0:000576		PANTR20110
Saccharomyces cerevisiae S288C	855385		SGD:S000005275
Monodelphis domestica	100027677			MONDO24714
Ornithorhynchus anatinus	100085489			ORNAN23007
Ciona intestinalis	100187122			CIOIN14420
Taeniopygia guttata	100190058			TAEGU12796

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements