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solute carrier family 25 member 12

Summary

Gene Symbol

SLC25A12

Organism

Homo sapiens (human)

External Links

NCBI Gene

8604

PubChem

8604

Alliance of Genome Resources

HGNC:10982

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Calcium
Disease variant
Metal-binding
Mitochondrion inner membrane
Reference proteome
Repeat
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
O75746	Araceli hiperlarga Mitochondrial aspartate glutamate carrier 1 Solute carrier family 25 member 12

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
neutral amino acid transport	IEA
aspartate transmembrane transport	IDA	11566871 19641205 24515575
aspartate transmembrane transport	IBA
L-glutamate transmembrane transport	IDA	11566871 19641205 24515575
L-glutamate transmembrane transport	IBA

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

mitochondrial transmembrane transport [inference]

malate-aspartate shuttle

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion

response to salt [inference]

response to calcium ion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

mitochondrial transport [inference]

mitochondrial transmembrane transport [inference]

malate-aspartate shuttle

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

mitochondrial transmembrane transport [inference]

malate-aspartate shuttle

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-glutamate import [inference]

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport

L-aspartate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

acidic amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

neutral amino acid transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

amide transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mitochondrion	IDA	11566871 19641205 24515575 9722566
mitochondrion	HTP	34800366
mitochondrion	HDA	20833797
mitochondrial inner membrane	TAS
mitochondrial inner membrane	IDA	11566871

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
3-sulfino-L-alanine: proton, glutamate antiporter activity	IDA	11566871
aspartate:glutamate, proton antiporter activity	IDA	11566871 24515575
L-glutamate transmembrane transporter activity	IBA
calcium ion binding	IDA	25410934 9722566
protein binding	IPI	28514442 31767682 33961781

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

sulfur-containing amino acid secondary active transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

acidic amino acid transmembrane transporter activity [inference]

neutral L-amino acid transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

L-amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

C4-dicarboxylate transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

sulfur-containing amino acid secondary active transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

acidic amino acid transmembrane transporter activity [inference]

neutral L-amino acid transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

L-amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

C4-dicarboxylate transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

sulfur-containing amino acid secondary active transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

amino acid:monoatomic cation antiporter activity [inference]

amide transmembrane transporter activity [inference]

modified amino acid transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

sulfur compound transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

sulfur-containing amino acid secondary active transmembrane transporter activity [inference]

3-sulfino-L-alanine: proton, glutamate antiporter activity

salt transmembrane transporter activity [inference]

binding [inference]

protein binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Mitochondrial carrier

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
L-aspartate transmembrane transporter activity
L-glutamate transmembrane transporter activity
calcium ion binding
malate-aspartate shuttle

Displaying **all 6** entries
InterPro
EF-Hand 1, calcium-binding site
EF-hand domain pair
EF-hand domain
Mitochondrial carrier domain superfamily
Mitochondrial carrier protein
Mitochondrial substrate/solute carrier

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050432	Asperger syndrome	Alliance of Genome Resources
DOID:0080349	developmental and epileptic encephalopathy 39	Alliance of Genome Resources
DOID:12849	autistic disorder	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **105** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	8604	Xenbase:XB-GENE-1002100
Saccharomyces cerevisiae S288C	10165	SGD:S000006225
Xenopus tropicalis	43616	Xenbase:XB-GENE-1002100
Saccharomyces cerevisiae S288C	50799	SGD:S000006225
Mus musculus	78830		MOUSE32458
Danio rerio	337675		DANRE38781
Rattus norvegicus	362145		RATNO28024
Canis lupus familiaris	478798		CANLF13962
Bos taurus	539494		BOVIN24072
Macaca mulatta	695173		MACMU07152

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