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phospholipid phosphatase 2

Summary

Gene Symbol

PLPP2

Aliases

LPP2
PAP-2c

Organism

Homo sapiens (human)

External Links

NCBI Gene

8612

HGNC

9230

KEGG Gene ID

hsa:8612

PubChem

8612

Alliance of Genome Resources

HGNC:9230

Annotation

Keyword

Alternative splicing
Cell membrane
Endoplasmic reticulum
Endosome
Glycoprotein
Hydrolase
Lipid metabolism
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O43688	Lipid phosphate phosphohydrolase 2 PAP2-gamma Phosphatidate phosphohydrolase type 2c Phosphatidic acid phosphatase 2c

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
phospholipid metabolic process	IBA IDA IEA	16467304 9705349

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

dephosphorylation [inference]

phospholipid dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

phospholipid metabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

phospholipid metabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

phospholipid metabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

cellular process [inference]

signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

dephosphorylation [inference]

phospholipid dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

phospholipid metabolic process

lipid modification [inference]

phospholipid dephosphorylation

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
early endosome membrane	IEA
caveola	IDA	16467304

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	25416956 25910212 32296183
ceramide-1-phosphate phosphatase activity	IDA	9705349
phosphatidate phosphatase activity	IBA IDA	16467304 9705349
sphingosine-1-phosphate phosphatase activity	IDA TAS	9705349

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

lipid phosphatase activity [inference]

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphatidic acid phosphatase type 2/haloperoxidase

Functional Category

I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
phospholipid dephosphorylation
phospholipid metabolic process

Displaying **all 2** entries
InterPro
Phosphatidate (PA) phosphatase-related
Phosphatidic acid phosphatase type 2/haloperoxidase superfamily

KEGG BRITE Database

Orthology

K01080

Name

phosphatidate phosphatase [EC:3.1.3.4]

References

Rhea

H₂O + a 1,2-diacyl-sn-glycero-3-phosphate

a 1,2-diacyl-sn-glycerol + phosphate

Enzyme

3.1.3.4

PMID

H₂O + 1-O-alkyl-2-acyl-sn-glycero-3-phosphate

phosphate + 1-O-alkyl-2-acyl-sn-glycerol

Enzyme

3.1.3.4

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001580
Gene Name: phosphatidic acid phosphatase type 2C

Ortholog

Displaying entries **31 - 40** of **106** in total

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Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Takifugu rubripes	101065874			TAKRU34188
Takifugu rubripes	101070467			TAKRU26983
Felis catus	101088986			FELCA03910
Gorilla gorilla gorilla	101127981	9595_0:004edc		GORGO15838
Jaculus jaculus	101599057			JACJA06058
Heterocephalus glaber	101725640			HETGA27430
Ficedula albicollis	101819263			FICAL10775
Chrysemys picta bellii	101945684			CHRPI08218
Ictidomys tridecemlineatus	101968154			ICTTR06046
Macaca fascicularis	102126222			MACFA16661

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Acknowledgements

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024