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sestrin-like protein

Summary

Gene Symbol

DDB_G0279427

Organism

Dictyostelium discoideum AX4

External Links

NCBI Gene: 8622027
PubChem: 8622027

Annotation

Keyword

Cytoplasm
Glycoprotein
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q54WU6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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2

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GO Term	Evidence Code	PMID
negative regulation of gene expression	IMP	30744820
positive regulation of macroautophagy	IMP	30744820
positive regulation of macroautophagy	IBA
negative regulation of TOR signaling	IMP	30744820
negative regulation of TOR signaling	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation [inference]

cellular response to leucine starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation [inference]

cellular response to leucine starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation [inference]

cellular response to leucine starvation

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to diterpene

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation [inference]

cellular response to leucine starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation [inference]

cellular response to leucine starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation [inference]

cellular response to leucine starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation [inference]

cellular response to leucine starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation [inference]

cellular response to leucine starvation

response to amino acid starvation [inference]

cellular response to amino acid starvation [inference]

cellular response to leucine starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation [inference]

cellular response to leucine starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation [inference]

cellular response to leucine starvation

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to leucine [inference]

cellular response to leucine

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

response to leucine [inference]

cellular response to leucine

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to lipid [inference]

cellular response to lipid [inference]

cellular response to diterpene

response to diterpene [inference]

cellular response to diterpene

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to diterpene

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to diterpene

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

response to leucine [inference]

cellular response to leucine

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to oxygen-containing compound [inference]

response to amino acid [inference]

response to leucine [inference]

cellular response to leucine

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation [inference]

cellular response to leucine starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to amino acid starvation [inference]

cellular response to leucine starvation

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to diterpene

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

regulation of TORC1 signaling [inference]

negative regulation of TORC1 signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

regulation of TORC1 signaling [inference]

negative regulation of TORC1 signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

regulation of response to stress [inference]

regulation of response to oxidative stress [inference]

regulation of response to reactive oxygen species

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

regulation of TORC1 signaling [inference]

negative regulation of TORC1 signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of TORC1 signaling

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IEA
cytoplasm	IEA
cytosol	IDA	30744820

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
oxidoreductase activity, acting on peroxide as acceptor	IBA
leucine binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor

binding [inference]

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

leucine binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

leucine binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sestrin

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
cellular response to leucine starvation
cellular response to leucine
cellular response to stimulus
leucine binding
negative regulation of TORC1 signaling
oxidoreductase activity, acting on peroxide as acceptor
positive regulation of macroautophagy
regulation of response to reactive oxygen species

Displaying **all 2** entries
InterPro
AhpD-like
Sestrin

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements