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MIRAGE

unc-5 netrin receptor C

Summary

Gene Symbol

UNC5C

Organism

Homo sapiens (human)

External Links

NCBI Gene

8633

PubChem

8633

Alliance of Genome Resources

HGNC:12569

Annotation

Keyword

Alternative splicing
Alzheimer disease
Amyloidosis
Apoptosis
Cell membrane
Cell projection
Developmental protein
Disulfide bond
Glycoprotein
Immunoglobulin domain
Neurodegeneration
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Synaptosome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O95185	Protein unc-5 homolog 3 Protein unc-5 homolog C
A8K385

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
apoptotic process	IEA
axon guidance	IBA
brain development	IEA
anterior/posterior axon guidance	IEA
ectopic germ cell programmed cell death	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

anterior/posterior axon guidance

reproductive process [inference]

developmental process involved in reproduction [inference]

ectopic germ cell programmed cell death

developmental process [inference]

developmental process involved in reproduction [inference]

ectopic germ cell programmed cell death

anatomical structure development [inference]

tissue development [inference]

ganglion development [inference]

dorsal root ganglion development

animal organ development [inference]

brain development

cellular developmental process [inference]

programmed cell death involved in cell development [inference]

ectopic germ cell programmed cell death

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis [inference]

chemorepulsion of axon

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of neuron migration

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of developmental process [inference]

positive regulation of developmental process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

netrin-activated signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of neuron migration

regulation of reproductive process [inference]

positive regulation of reproductive process

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
plasma membrane	IDA	25419706
cell surface	IEA
lamellipodium	ISS
filopodium	ISS
dendrite	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

synapse

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection [inference]

dendrite

actin-based cell projection [inference]

filopodium

cell body [inference]

neuronal cell body

Displaying **all 5** entries
GO Term	Evidence Code	PMID
netrin receptor activity	IBA
netrin receptor activity involved in chemorepulsion	ISS
protein binding	IPI	22685302 28483977
tubulin binding	IPI	28483977
protein kinase binding	IPI	27068745

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

tubulin binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

netrin receptor activity

netrin receptor activity involved in chemorepulsion

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

unc-5 netrin receptor A

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
netrin receptor activity
netrin-activated signaling pathway

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InterPro
Death domain
Death-like domain superfamily
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold
Netrin receptor UNC5
Thrombospondin type-1 (TSP1) repeat superfamily

Ortholog

Displaying entries **21 - 30** of **120** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Oryctolagus cuniculus	100351024		RABIT05214
Callithrix jacchus	100397357		CALJA28575
Pongo abelii	100443113		PONAB27909
Ailuropoda melanoleuca	100467303		AILME16802
Meleagris gallopavo	100544549		MELGA10038
Nomascus leucogenys	100599418		NOMLE37604
Sus scrofa	100621284		PIGXX34405
Loxodonta africana	100664742		LOXAF14168
Oreochromis niloticus	100689753		ORENI11653
Oreochromis niloticus	100698253		ORENI66447

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025