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Guidelines

MIRAGE

amine oxidase copper containing 3

Summary

Gene Symbol

AOC3

Organism

Homo sapiens (human)

External Links

NCBI Gene

8639

PubChem

8639

Alliance of Genome Resources

HGNC:550

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Copper
Direct protein sequencing
Disulfide bond
Glycoprotein
Metal-binding
Oxidoreductase
Reference proteome
Signal-anchor
TPQ
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9UEU7
Q16853	Amine oxidase copper-containing 3 Copper amine oxidase HPAO Semicarbazide-sensitive amine oxidase Vascular adhesion protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
inflammatory response	TAS	9653080
cell adhesion	IDA	9653080
amine metabolic process	IDA	9653080
amine metabolic process	IBA
response to antibiotic

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amine metabolic process

organic substance metabolic process [inference]

organonitrogen compound metabolic process [inference]

amine metabolic process

cellular process [inference]

cell adhesion

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to chemical [inference]

response to antibiotic

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	23349812
early endosome	IDA	23474851
early endosome	IBA
endoplasmic reticulum	IDA	23474851
endoplasmic reticulum	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
copper ion binding	IDA	16046623
copper ion binding	IBA
calcium ion binding	IDA	16046623
protein binding	IPI	23349812 32296183 32814053
primary amine oxidase activity	IDA	19588076 23349812 23474851 9653080

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-NH2 group of donors [inference]

oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [inference]

binding [inference]

protein binding

identical protein binding

protein dimerization activity [inference]

protein heterodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

copper ion binding

quinone binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Amine oxidase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
copper ion binding
metal ion binding
oxidoreductase activity
quinone binding

Displaying **all 6** entries
InterPro
Copper amine oxidase, N-terminal
Copper amine oxidase, N2-terminal
Copper amine oxidase, N3-terminal
Copper amine oxidase, catalytic domain superfamily
Copper amine oxidase, catalytic domain
Copper amine oxidase

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	314	Xenbase:XB-GENE-941577
Xenopus tropicalis	8639	Xenbase:XB-GENE-941577
Mus musculus	11754	Xenbase:XB-GENE-941577	MOUSE04469
Xenopus tropicalis	29473	Xenbase:XB-GENE-941577
Xenopus tropicalis	237940	Xenbase:XB-GENE-941577
Bos taurus	281002		BOVIN13418
Pan troglodytes	454702		PANTR13822
Canis lupus familiaris	480511		CANLF18675
Danio rerio	541429		DANRE31706
Macaca mulatta	708053		MACMU14658

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025