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eukaryotic translation initiation factor 3 subunit F

Summary

Gene Symbol

EIF3F

Organism

Homo sapiens (human)

External Links

NCBI Gene

8665

PubChem

8665

Alliance of Genome Resources

HGNC:3275

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Disease variant
Initiation factor
Intellectual disability
Phosphoprotein
Reference proteome
Thiol protease
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
O00303	Deubiquitinating enzyme eIF3f Eukaryotic translation initiation factor 3 subunit 5 eIF-3-epsilon eIF3 p47

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
proteolysis	IEA
translational initiation	IBA IC IDA	17322308 17581632 18599441
IRES-dependent viral translational initiation	IDA	9573242
formation of cytoplasmic translation initiation complex	NAS	16920360

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular metabolic process [inference]

translational initiation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cellular metabolic process [inference]

translational initiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of cytoplasmic translation initiation complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of cytoplasmic translation initiation complex

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

formation of cytoplasmic translation initiation complex

viral process [inference]

IRES-dependent viral translational initiation

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GO Term	Evidence Code	PMID
eukaryotic translation initiation factor 3 complex	IDA IPI TAS	17322308 17581632 18599441 25849773 9341143
membrane	HDA	19946888
eukaryotic 43S preinitiation complex	IEA
eukaryotic 48S preinitiation complex	IEA
eukaryotic translation initiation factor 3 complex, eIF3m	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation initiation factor 3 complex

eukaryotic translation initiation factor 3 complex, eIF3m

ribonucleoprotein complex [inference]

translation preinitiation complex [inference]

cellular anatomical entity [inference]

cell junction [inference]

synapse

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16169070 18231581 18354498 18599441 18628297 18724935 19245811 19748344 22190034 23275563 23623729 23725059 24243016 24396066 25416956 28514442 32296183 32814053 33961781 35271311
translation initiation factor binding	IBA
translation initiation factor activity	IBA IC IDA TAS	17322308 17581632 18599441 25849773 9341143
cysteine-type deubiquitinase activity	IEA
identical protein binding	IPI	32296183

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

metallopeptidase activity [inference]

metal-dependent deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

metallopeptidase activity [inference]

metal-dependent deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Eukaryotic translation initiation factor 3 subunit F

Functional Category

H: Coenzyme transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cytoplasmic translational initiation
formation of cytoplasmic translation initiation complex
metallopeptidase activity
translation initiation factor binding

Displaying **all 4** entries
InterPro
EIF3F/CSN6-like, C-terminal
Eukaryotic translation initiation factor 3 subunit F
JAB1/MPN/MOV34 metalloenzyme domain
MPN domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0081228	autosomal recessive intellectual developmental disorder 67	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **109** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	35547		FB:FBgn0033069
Drosophila melanogaster	40587		FB:FBgn0037270
Mus musculus	66085		MGI:1913335	MOUSE52890
Caenorhabditis elegans	174478		WB:WBGene00001229
Rattus norvegicus	293427		RGD:1306112	RATNO21177
Pan troglodytes	451007	9598_0:002fa3		PANTR02244
Bos taurus	513793			BOVIN06836
Xenopus tropicalis	548944		Xenbase:XB-GENE-5898648
Danio rerio	557270		ZFIN:ZDB-GENE-100215-2	DANRE18212
Equus caballus	100070877			HORSE38901

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements