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eukaryotic translation initiation factor 3 subunit F

Summary

Gene Symbol

EIF3F

Organism

Homo sapiens (human)

External Links

NCBI Gene

8665

PubChem

8665

Alliance of Genome Resources

HGNC:3275

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Disease variant
Initiation factor
Intellectual disability
Phosphoprotein
Reference proteome
Thiol protease
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
O00303	Deubiquitinating enzyme eIF3f Eukaryotic translation initiation factor 3 subunit 5 eIF-3-epsilon eIF3 p47

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
formation of cytoplasmic translation initiation complex	NAS	16920360
translational initiation	IC	17322308 18599441
translational initiation	IDA	17581632
translational initiation	IBA
proteolysis	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular metabolic process [inference]

translational initiation

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cellular metabolic process [inference]

translational initiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of cytoplasmic translation initiation complex

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of cytoplasmic translation initiation complex

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

formation of cytoplasmic translation initiation complex

viral process [inference]

IRES-dependent viral translational initiation

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GO Term	Evidence Code	PMID
cytosol	TAS
eukaryotic translation initiation factor 3 complex	TAS	9341143
eukaryotic translation initiation factor 3 complex	IDA	17322308 17581632 18599441 25849773
eukaryotic translation initiation factor 3 complex	IPI	17322308
membrane	HDA	19946888

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation initiation factor 3 complex

eukaryotic translation initiation factor 3 complex, eIF3m

ribonucleoprotein complex [inference]

translation preinitiation complex [inference]

cellular anatomical entity [inference]

cell junction [inference]

synapse

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GO Term	Evidence Code	PMID
translation initiation factor activity	TAS	9341143
translation initiation factor activity	IC	17322308 18599441
translation initiation factor activity	IDA	17581632 25849773
translation initiation factor activity	IBA
cysteine-type deubiquitinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

metallopeptidase activity [inference]

metal-dependent deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

metallopeptidase activity [inference]

metal-dependent deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Eukaryotic translation initiation factor 3

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
metallopeptidase activity

Displaying **all 3** entries
InterPro
EIF3F/CSN6-like, C-terminal
JAB1/MPN/MOV34 metalloenzyme domain
MPN domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081228	autosomal recessive intellectual developmental disorder 67	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	8665	Xenbase:XB-GENE-5898648
Mus musculus	66085	Xenbase:XB-GENE-5898648	MOUSE52890
Rattus norvegicus	293427		RATNO21177
Pan troglodytes	451007		PANTR02244
Bos taurus	513793		BOVIN06836
Danio rerio	557270		DANRE18212
Equus caballus	100070877		HORSE38901
Equus caballus	100071582		HORSE38901
Ornithorhynchus anatinus	100084593		ORNAN15478
Ciona intestinalis	100183816		CIOIN07391

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External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements