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polypeptide N-acetylgalactosaminyltransferase 4

Summary

Gene Symbol

GALNT4

Aliases

GalNAc-T4
polypeptide GalNAc transferase 4

Organism

Homo sapiens (human)

External Links

NCBI Gene

8693

GGDB ID

gg090

HGNC

4126

mRNA

NM_003774

map

12q21.3-q22

Protein

NP_003765

OMIM

603565

KEGG Gene ID

hsa:8693

PubChem

8693

Alliance of Genome Resources

HGNC:4126

Annotation

Keyword

3D-structure
Alternative splicing
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lectin
Manganese
Metal-binding
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8N4A0	Polypeptide GalNAc transferase 4 Protein-UDP acetylgalactosaminyltransferase 4 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein O-linked glycosylation	IBA
protein O-linked glycosylation via threonine	IDA	29208955 9804815
O-glycan processing	TAS
protein O-linked glycosylation via serine	IDA	9804815

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

protein O-linked glycosylation via serine

peptidyl-threonine modification [inference]

protein O-linked glycosylation via threonine

Displaying **all 4** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IDA	12506059
perinuclear region of cytoplasm	IDA	12506059
extracellular exosome	HDA	19199708
Golgi membrane	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

Displaying **all 4** entries
GO Term	Evidence Code	PMID
manganese ion binding	IDA	29208955
carbohydrate binding	IEA
protein binding	IPI	32814053
polypeptide N-acetylgalactosaminyltransferase activity	IBA IDA TAS	29208955 9804815

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

polypeptide N-acetylgalactosaminyltransferase activity

hexosyltransferase activity [inference]

acetylgalactosaminyltransferase activity [inference]

polypeptide N-acetylgalactosaminyltransferase activity

catalytic activity, acting on a protein [inference]

polypeptide N-acetylgalactosaminyltransferase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

manganese ion binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg090

Gene Symbol

GALNT4

Orthologous Gene

Displaying **all 4** entries
Species	Protein	mRNA
Rattus norvegicus	NP_001020224	NM_001025053
Drosophila melanogaster	NP_725602	NM_166188
Caenorhabditis elegans	NP_499721	NM_067320
Mus musculus	NP_056552	NM_015737

KEGG BRITE Database

Orthology

K00710

Name

polypeptide N-acetylgalactosaminyltransferase [EC:2.4.1.41]

References

9295285

Rhea

RHEA:23956

UDP-N-acetyl-α-D-galactosamine

H⁺ + UDP

Enzyme

2.4.1.41

PMID

RHEA:52424

UDP-N-acetyl-α-D-galactosamine

H⁺ + UDP

Enzyme

2.4.1.41

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 13 in total

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DO ID	Disease Name	Source
DOID:10283	prostate cancer	DisGeNET
DOID:10286	prostate carcinoma	DisGeNET
DOID:1520	colon carcinoma	DisGeNET
DOID:1584	acute chest syndrome	DisGeNET
DOID:1612	breast cancer	DisGeNET
DOID:162	cancer	DisGeNET
DOID:1936	atherosclerosis	DisGeNET
DOID:219	colon cancer	DisGeNET
DOID:2348	arteriosclerotic cardiovascular disease	DisGeNET
DOID:235	colonic benign neoplasm	DisGeNET

Ortholog

Displaying entries **1 - 10** of 34 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	176736	WB:WBGene00001630
Drosophila melanogaster	246627	FB:FBgn0050463
Callorhinchus milii	103186345		CALMI34446
Latimeria chalumnae	102348504		LATCH10917
Danio rerio	503760	ZFIN:ZDB-GENE-050306-41	DANRE15026
Astyanax mexicanus	103026965		ASTMX12260
Ictalurus punctatus	108257092		ICTPU19210
Electrophorus electricus	113590032		ELEEL44442
Salmo salar	106570445		SALSA36200
Salmo salar	106588954		SALSA96849

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

International Collaboration

Acknowledgements