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dynein axonemal heavy chain 11

Summary

Gene Symbol

DNAH11

Organism

Homo sapiens (human)

External Links

NCBI Gene

8701

PubChem

8701

Alliance of Genome Resources

HGNC:2942

Annotation

Keyword

ATP-binding
Cilium
Coiled coil
Cytoskeleton
Disease variant
Dynein
Kartagener syndrome
Microtubule
Motor protein
Reference proteome
Repeat

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q96DT5	Axonemal beta dynein heavy chain 11 Ciliary dynein heavy chain 11
H9NAJ7
H9NAJ8
Q96NT7

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
cilium movement involved in cell motility	IBA
epithelial cilium movement involved in determination of left/right asymmetry	IEA
determination of left/right asymmetry in nervous system	IEA
regulation of cilium beat frequency	IMP	18022865 22184204 22499950
protein localization to motile cilium	IMP	33139725

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

epithelial cilium movement involved in determination of left/right asymmetry

cilium movement involved in cell motility

flagellated sperm motility

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium [inference]

protein localization to motile cilium

reproductive process [inference]

sperm motility [inference]

flagellated sperm motility

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory

pattern specification process [inference]

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

determination of left/right asymmetry in nervous system

behavior [inference]

learning or memory

developmental process [inference]

anatomical structure morphogenesis [inference]

cardiac septum morphogenesis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium [inference]

protein localization to motile cilium

establishment of localization [inference]

transport [inference]

extracellular transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

epithelial cilium movement involved in determination of left/right asymmetry

microtubule-based transport [inference]

epithelial cilium movement involved in extracellular fluid movement [inference]

epithelial cilium movement involved in determination of left/right asymmetry

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to cilium [inference]

protein localization to motile cilium

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of microtubule-based process [inference]

regulation of microtubule-based movement [inference]

regulation of cilium movement [inference]

regulation of cilium beat frequency

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
microtubule	IEA
dynein complex	IBA
9+2 motile cilium	IBA IDA	26909801
9+0 motile cilium	IEA
motile cilium	IDA	31178125

GO Hierarchy

cellular component

protein-containing complex [inference]

microtubule associated complex [inference]

dynein complex

catalytic complex [inference]

dynein complex

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

proximal portion of axoneme

Displaying **all 5** entries
GO Term	Evidence Code	PMID
minus-end-directed microtubule motor activity	IBA
dynein intermediate chain binding	IBA
ATP hydrolysis activity	IEA
dynein light intermediate chain binding	IBA
ATP binding	IEA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microtubule motor activity [inference]

minus-end-directed microtubule motor activity

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microtubule motor activity [inference]

minus-end-directed microtubule motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dyneins heavy chain

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
InterPro
Kelch-type beta propeller

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050144	Kartagener syndrome	Alliance of Genome Resources
DOID:0050545	visceral heterotaxy	Alliance of Genome Resources
DOID:0050651	atrioventricular septal defect	Alliance of Genome Resources
DOID:0110605	primary ciliary dyskinesia 7	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 50 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	13411		MGI:1100864	MOUSE08720
Drosophila melanogaster	43295		FB:FBgn0039510
Rattus norvegicus	117253		RGD:621088	RATNO35720
Canis lupus familiaris	482346			CANLF03727
Danio rerio	552915		ZFIN:ZDB-GENE-050506-1
Callithrix jacchus	100399216			CALJA42702
Pongo abelii	100456482	9601_0:0021a0		PONAB33560
Xenopus laevis	100462917		Xenbase:XB-GENE-6488653
Xenopus tropicalis	100494270		Xenbase:XB-GENE-950720
Nomascus leucogenys	100584743			NOMLE02753

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements