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cathepsin F

Summary

Gene Symbol

CTSF

Organism

Homo sapiens (human)

External Links

NCBI Gene

8722

PubChem

8722

Alliance of Genome Resources

HGNC:2531

Annotation

Keyword

3D-structure
Disease variant
Disulfide bond
Glycoprotein
Lysosome
Neuronal ceroid lipofuscinosis
Reference proteome
Signal
Thiol protease
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UBX1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
proteolysis	TAS	9822672
antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
proteolysis involved in protein catabolic process	IBA

GO Hierarchy

biological process

immune system process [inference]

antigen processing and presentation [inference]

antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [inference]

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of exogenous antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

antigen processing and presentation of peptide antigen via MHC class II [inference]

antigen processing and presentation of exogenous peptide antigen via MHC class II

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

proteolysis involved in protein catabolic process

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular space	IBA
lysosome	IBA
endoplasmic reticulum	IDA
plasma membrane	IDA
lysosomal lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle

extracellular exosome

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cysteine-type endopeptidase activity	TAS
cysteine-type endopeptidase activity	IBA
protein binding	IPI	15752368
cysteine-type peptidase activity	IDA	15752368

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cathepsin S

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
V: Defense mechanisms

Displaying **all 4** entries
Gene Ontology
cysteine-type endopeptidase activity
hydrolase activity
proteolysis involved in protein catabolic process
proteolysis

Displaying **all 8** entries
InterPro
Cathepsin propeptide inhibitor domain (I29)
Cysteine peptidase, asparagine active site
Cysteine peptidase, cysteine active site
Cysteine peptidase, histidine active site
Papain-like cysteine endopeptidase
Papain-like cysteine peptidase superfamily
Peptidase C1A, papain C-terminal
Peptidase C1A

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110727	neuronal ceroid lipofuscinosis 13	Alliance of Genome Resources

Ortholog

Displaying entries **41 - 50** of 60 in total

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Species	Gene ID	Orthologous MAtrix
Equus asinus asinus	106833524	EQUAS27194
Sinocyclocheilus grahami	107559296	SINGR61076
Sinocyclocheilus grahami	107587086	SINGR41420
Rhinopithecus bieti	108518671	RHIBE20937
Phascolarctos cinereus	110195406	PHACI17024
Vulpes vulpes	112924208	VULVU17859
Electrophorus electricus	113573387	ELEEL13168
Bos indicus x Bos taurus	113886135	BOBOX00159
Vombatus ursinus	114038634	VOMUR24485
Salmo trutta	115168960	SALTR42731

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OrthoDB (Group)

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Acknowledgements