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ADAM metallopeptidase domain 19

Summary

Gene Symbol

ADAM19

Organism

Homo sapiens (human)

External Links

NCBI Gene

8728

PubChem

8728

Alliance of Genome Resources

HGNC:197

Annotation

Keyword

Alternative splicing
Disulfide bond
EGF-like domain
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
SH3-binding
Signal
Transmembrane helix
Zinc
Zymogen

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9H013	Meltrin-beta Metalloprotease and disintegrin dendritic antigen marker
Q8TBU7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
placenta development	IEP	19727588
membrane protein ectodomain proteolysis	IBA
positive regulation of gene expression	IDA	19727588
protein processing	IMP	17112471
amyloid precursor protein catabolic process	IMP	17112471

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

amyloid precursor protein metabolic process [inference]

amyloid precursor protein catabolic process

protein maturation [inference]

protein processing

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

placenta development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion mediated by cadherin

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion mediated by cadherin

regulation of cell-cell adhesion mediated by cadherin [inference]

positive regulation of cell-cell adhesion mediated by cadherin

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion mediated by cadherin

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion mediated by cadherin

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	IDA	19727588
plasma membrane	TAS
collagen-containing extracellular matrix	HDA	28344315

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
metalloendopeptidase activity	IMP	11162584 17112471
metalloendopeptidase activity	IBA
protein binding	IPI	11162584 17112471 25825872 33961781
SH3 domain binding	IEA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metallopeptidase activity [inference]

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

metallopeptidase activity [inference]

metalloendopeptidase activity

metalloendopeptidase activity involved in amyloid precursor protein catabolic process

binding [inference]

protein binding

protein domain specific binding [inference]

SH3 domain binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Disintegrin

Functional Category

M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
metal ion binding
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 9** entries
InterPro
ADAM, cysteine-rich domain
Disintegrin domain superfamily
Disintegrin domain
Disintegrin, conserved site
EGF-like domain
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin
Peptidase M12B, propeptide
Reprolysin domain, adamalysin-type

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	101	FB:FBgn0265140
Drosophila melanogaster	8038	FB:FBgn0265140
Xenopus laevis	8728	Xenbase:XB-GENE-5990454
Drosophila melanogaster	8751	FB:FBgn0265140
Drosophila melanogaster	8754	FB:FBgn0265140
Drosophila melanogaster	8756	FB:FBgn0265140
Drosophila melanogaster	10863	FB:FBgn0265140
Drosophila melanogaster	11085	FB:FBgn0265140
Drosophila melanogaster	11489	FB:FBgn0265140
Drosophila melanogaster	11490	FB:FBgn0265140